职业对臭氧联合胶原酶靶点溶盘治疗腰椎间盘突出症的影响  

Effect of occupation on ozone-collagenase target disclysis of lumbar disc herniation

作　　者：王忠三[1] 刘一成[1] 徐葵[1] 陈敏[1] 熊力[1] 何博[1] 

机构地区：[1]湖北航天医院,湖北孝感432000

出　　处：《中国现代医药杂志》2013年第7期38-40,共3页Modern Medicine Journal of China

摘　　要：目的回顾性分析职业因素对臭氧联合胶原酶靶点溶盘治疗腰椎间盘突出症治疗效果及不良反应的影响。方法 120例患者按职业分类:工人、农民、其他(科教文卫、商人、军警等)各40例,分别对临床效果优良率、不良反应发生率与随访时间、职业进行关联性检验,分析随访时间、职业对临床效果优良率、不良反应发生率的影响度。结果①术后随访时间与总体临床效果优良率密切关联(P<0.05)。②职业与总体临床效果优良率关联性不密切(P>0.05)。不同职业于不同随访时间临床效果组间对照比较:工人组6月优良率明显低于同期另外两组(P<0.05),其他组术后3月、其他组术后1月优良率明显高于同期另外两组(P<0.05)。③职业与总体不良反应发生率关联性不密切(P>0.05);不同职业于不同随访时间不良反应发生率组间比较:农民组术后1周、农民组术后6月不良反应发生率明显高于同期另外两组(P<0.05),其他组术后1月不良反应发生率明显低于同期另外两组(P<0.05);即在某时间段职业对不良反应发生率明显影响。结论①随访时间不同对总体治疗效果影响明显,3～6月后效果明显优于1周或1月;②职业与总体临床效果优良率及不良反应发生率关联性不密切,即职业对总体治疗效果及不良反应发生率无明显影响,但某些时间段职业对临床效果及不良反应发生率明显影响。Objective To analyze the occupational factor affects retrospectively on the treatment effect and adverse drug reaction of ozone-collagenase target disclysis of lumbar disc herniation. Methods One hundred and twenty patients were di- vided into groups by occupation that were worker group （40 patients）, peasant group （40 patients） and other occupational group including staff engaging in science, education, art and health, businessman and police （40 patients）. The rates of good clinical result or adverse drug reaction were examined associatively with follow-up visit time and occupation. The effect degree of the follow-up visit time and occupation to the rates of good clinical result or adverse drug reaction was analyzed respectively. Re- sults ①There was close association of the rate of good clinical result to the post-operation follow-up visit time （P〈0.05）. ②There was not close association of the rate of good clinical result to occupation （P〉0.05）. Comparison of the rate of good clinical result among groups at different follow-up visit time： the worker group in 6 months after operation was lower than that of the other two groups （P〈0.05）, the other occupational group in 1 or 3 months after operation were higher than that of the other two groups at the same time （P〈0.05）. ③There was not close association of the rate of adverse drug reaction to occupation. Compari- son of the rate of adverse drug reaction among groups at the different follow-up visit time ： the peasant group in one week or 6 months after operation were higher than those of the other two groups at the same time（P〈0.05）, the other occupational group in one month after operation was lower than that of the other two groups （P〈0.05）. Different occupation affected significantly the general rate of adverse drug reaction at a certain period of time. Conclusion ①There is significant treatment effect at differ- ent follow-up visit time. The treatment effect in 3 or 6 months is better significantly th

关 键 词：职业 椎间盘 胶原酶 臭氧 

分 类 号：R681.53[医药卫生—骨科学]