抗胸腺细胞球蛋白联合脐带间充质干细胞治疗重型再生障碍性贫血1例  

Effect of antithymocyte globulin and umbilical cord-derived mesenchymal stem cells on patients with severe aplastic anemia

作　　者：王方方[1] 顾健[1] 何斌[1] 谢晓艳[1] 

机构地区：[1]江苏省苏北人民医院血液科扬州市血液学研究所,江苏扬州225001

出　　处：《临床血液学杂志》2013年第4期450-451,454,共3页Journal of Clinical Hematology

摘　　要：目的:探索脐带间充质干细胞(UC-MSCs)与抗胸腺细胞球蛋白(ATG)联合治疗重型再生障碍性贫血患者的可行性、安全性和作用机制。方法:采用UC-MSCs联合ATG治疗1例重型再生障碍性贫血Ⅰ型,观察血常规、网织红细胞、骨髓细胞学变化,采用流式细胞仪检测干扰素(IFN)-γ、调节T细胞(Treg)变化。结果:UC-MSCs输注后2周,患者血细胞计数、网织红细胞计数开始上升,骨髓增生活跃,粒系和红系增生,输血间隔时间延长至每11～12d1次,IFN-γ水平下降,Treg细胞水平上升;无呼吸道感染及肝肾功能异常。结论:UC-MSCs与ATG联合治疗有利于促进再生障碍性贫血患者骨髓造血能力的恢复,无不良反应发生。Objective：To study the effect of umbilical cord-derived mesenchymal stem cells（UC-MSCs） combined with antithymocyte globulin（ATG） on patients with severe aplastic anemia（SAA）. Method：A patient of SAA-Ⅰ was treated with ATG and UC-MSCs.Blood cell count,reticulocyte and marrow hyperplasia were performed.Flow cytometry was used to determine IFN-γ and regulatory T cells（Treg）. Result：The blood cell count,reticulocyte and Treg of the patient elevated,bone marrow hyperplasia became more active than before,the interval time of blood transfusion extended and the level of IFN-γ descended.There was no respiratory infection,abnormality of the hepatic and renal function. Conclusion：ATG and UC-MSCs can improve the hematogenesis of bone marrow in aplastic anemia without obviously adverse reaction.

关 键 词：贫血 再生障碍性 脐带间充质干细胞 抗胸腺细胞球蛋白 造血功能 

分 类 号：R556.5[医药卫生—血液循环系统疾病]