三丙烯微球栓塞肾动脉的实验研究  

Tris-acryl gelatin microspheres used as an embolic agent for renal artery embolization: an experimental study in rabbits

作　　者：朱国庆[1] 虞希祥[1] 肖池金[1] 施振静[1] 施昌盛[1] 

机构地区：[1]温州医学院附属第三医院介入科,浙江瑞安325200

出　　处：《介入放射学杂志》2013年第7期578-581,共4页Journal of Interventional Radiology

基　　金：瑞安市科技局资助项目(201102035)

摘　　要：目的探讨三丙烯微球的动脉栓塞效果、不良反应及组织相容性。方法将36只日本大耳白兔随机分成A、B两组,每组18只。A组用三丙烯微球(300～500μm)栓塞右肾动脉;B组用聚乙烯醇(PVA)颗粒(300～500μm)栓塞右肾动脉。两组于术后1、4和8周分别随机抽取6只动物行肾动脉造影复查,并取肾脏行病理检查。结果两组栓塞后组织形态改变相似,在复通率、误栓率方面组间差异无统计学意义(P>0.05)。A组栓塞时间为(11.4±2.1)min,B组为(29.2±4.3)min,A组栓塞时间明显较B组缩短(P<0.05)。A组栓塞后血管周围炎症反应均较B组低(P<0.05),栓塞血管相符率较B组高。结论三丙烯微球与PVA颗粒动脉栓塞效果相似,安全有效,但三丙烯微球比PVA颗粒操作简便,可预见性强,组织相容性好,是值得临床应用和推广的栓塞剂。Objective To study the embolic effects of tris-acryl gelatin microspheres for renal artery embolization in experimental rabbits, and to discuss the side effects and tissue compatibility of tris- aeryl gelatin mierospheres. Methods A total of 36 Japanese white rabbits were randomly and equally divided into Group A and Group B. Group A （n = 18） received right renal artery embolization by using tris-acryl gelatin microspheres （300 - 500μ m） as the embolic agent, while Group B （n = 18） received fight renal artery embolization by using PVA particles （300 - 500 μm） as the embolic agent. Every six rabbits from group A and group B each time at one, 4 and 8 weeks after the embolization procedure were sacrificed after renal angiography. The kidneys were removed and sent for pathologic examination. The angiographie findings were analyzed. The results were compared between the two groups. Results After the embolization procedure the renal morphological changes in the two groups were similar. No statistically significant difference in re- canalization rate and non- target tissue embolization rate existed between the two groups （P 〉 0.05）. The average operation time in group A and group B was （11.4 _＋ 2.1） rain. and （29.2 ＋- 4.3） min. respectively. The operation time in group A was significantly shorter than that in Group B （P 〈 0.05）. Post-embolization perivaseular inflammatory reaction in group A was distinctly slighter than that in group B （P 〈 0.05）. The coincidence rate of obstructed vessels with scheduled target vessels in group A was higher than that in group B. Conclusion Both tris-acryl gelatin microspheres and PVA particles are effective and safe embolic agents. But the performance of embolization with tris- aeryl gelatin microspheres is technically simple with reliable predictability. Moreover, tris- acryl gelatin microsphere has better histological compatibility. Therefore, the use of tris- aeryl gelatin mierospheres as embolic agent should be advocated in clinical pr

关 键 词：肾动脉 栓塞 三丙烯微球 动物实验 

分 类 号：R543.5[医药卫生—心血管疾病]