血清氧化低密度脂蛋白升高对早发冠心病的预测价值  

The Predictive Value of Elevation in Serum Oxidized Low Density Lipoprotein for Premature Coronary Artery Disease

作　　者：师艳莉[1] 车京津[1] 李连[1] 张彦彦[1] 

机构地区：[1]天津医科大学第二医院心脏科,300211

出　　处：《天津医药》2013年第7期662-664,共3页Tianjin Medical Journal

摘　　要：目的探讨早发冠心病(PCAD)患者血清氧化低密度脂蛋白(ox-LDL)及传统心血管危险因子的特征。方法连续选取经冠状动脉造影术确诊的冠心病(CAD)患者66例选入PCAD组,冠脉血管正常的患者56例作为对照组。比较2组患者血清ox-LDL、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、血肌酐(SCr)、尿酸(UA)等生化指标水平及性别、冠心病家族史、体质指数、高血压史、糖尿病史、吸烟史等的差异。结果 (1)PCAD组血清ox-LDL、TG、SCr、UA、空腹血糖(FBG)水平及男性比例高于对照组(P<0.05),HDL-C水平低于对照组(P<0.05),其他指标2组间差异无统计学意义。(2)ox-LDL水平与UA、SCr水平呈正相关,rs分别为0.243(P=0.006)、0.186(P=0.034)。(3)Logistic回归分析显示:ox-LDL、HDL-C和SCr是PCAD的影响因素,OR值分别为1.155、0.143、1.052。结论 ox-LDL、HDL-C和SCr异常是PCAD的独立预测因素。Objective To investigate the characteristics of serum oxidized low density lipoprotein （ox-LDL） and traditional cardiovascular risk factors of premature coronary artery disease （PCAD）. Methods Sixty-six patients with coronary atrery disease （CAD） confirmed by angiography were selected to be PCAD group, and 56 patients with normal coronary artery confirmed by angiography were included in control group. The serum levels of ox-LDL, high density lipoprotein choles- terol （HDL-C）, triglyceride （TG）, creatinine （SCr）, uric acid （UA）, other serum biochemical indicators and differences of the proportions of male, hypertension, diabetes, smoking history and family history of CAD were compared between two groups. Results （1）There were higher serum values of ox-LDL, TG, SCr, UA, fasting blood glucose （FBG） and proportion of male pa- tients in PCAD group than those of control group （P 〈 0.05）, but there was a ｜ower plasma level of HDL-C in PCAD group than that of control group （P 〈 0.05）. There were significant differences in other indicators between two groups. （2） There were positive correlations between UA, SCr and ox-LDL （ r were 0.243 and 0.186 respectively, P were 0.006 and 0.034 respective- ly）. （3）The logistic regression analysis showed that ox-LDL, HDL-C and SCr were influential factors to PCAD（OR were 1.155, O. 143 and 1.052 respectively）. Conclusion Elevations of ox-LDL, HDL-C and SCr are independent predictors of PCAD.

关 键 词：冠状动脉疾病 脂蛋白类 LDL 危险因素 氧化低密度脂蛋白 

分 类 号：R543.5[医药卫生—心血管疾病]