尘肺患者血清神经烯醇化酶及铁蛋白含量的变化  

Changes of serum neuron-specific enolase and serum ferritin levels in patients with pneumoconiosis

作　　者：姜锋杰[1] 高顺姬[1] 孟军[1] 李桂芳[1] 孙晓娟[1] 

机构地区：[1]山东省潍坊市人民医院职业病科,261041

出　　处：《中华劳动卫生职业病杂志》2013年第7期534-535,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的探讨尘肺患者血清神经烯醇化酶（NSE）、铁蛋白（sF）含量变化与尘肺发病的关系。方法选择尘肺患者182例为尘肺病例组，60例接尘无尘肺病者为对照组，应用电化学荧光免疫分析法测定尘肺病患者外周血血清中NSE、SF的含量。结果I期尘肺及Ⅱ期尘肺患者血清中NSE[（23．0264±14．0410）、（44．9776±26．5208）ng／m11、SF含量（267．2515±186．5809）、（579．1371±433．9326）ng／m1]均明显高于对照组[NSE：（8．1480±3．7512）ng／ml、SF：（120．8613±74．2809）ng／m1]，且Ⅱ期尘肺患者NSE、SF含量明显高于I期，差异有统计学意义（P〈O．05）。与治疗前I（33．4490±21．6948）ng／m1]比较，治疗后的尘肺病患者血清NSE含量[（21．1675±17．5942）ng／m1]降低，但仍高于对照组[（8．1480±3．7512）ng／m11，差异有统计学意义（P〈0．05），治疗前后SF含量无明显变化。结论尘肺患者血清中NSE、SF升高。可能与尘肺病的发病和进展有一定关系。Objective To investigate the changes in serum neuron-specific enolase （NSE） and serum ferritin （SF） in patients with pneumoconiosis and their relationship with the onset of pneumoconiosis. Methods The serum NSE and SF levels in the peripheral blood of patients with pneumoconiosis were measured by electrochemical fluorescence immunoassay. Results The patients with first-stage pneumoconiosis and second- stage pneumoeoniosis had significantly higher serum NSE and SF levels than the control group （23.0264± 14.0410 and 44.9776±26.5208 ng/ml vs 8.1480±3.7512 ng/ml, P〈0.05; 267.2515±186.5809 and 579.1371± 433.9326 ng/ml vs 120.8613±74.2809 ng/ml, P〈0.05）, and the patients with second-stage pneumoconiosis had significantly higher serum NSE and SF levels than those with first-stage pneumoconiosis （P〈0.05）. After treatment, the serum NSE level decreased significantly in the patients with pneumoconiosis （21.1675±17.5942 ng/ml vs 33.4490±1.6948 ng/ml, P〈0.05 ）, but it was still significantly higher than that in the control group （P〈 0.05）. The treatment did not produce significant changes in SF level among these patients （P〉0.05）. Conclusion Patients with pneumoeoniosis have elevated serum NSE and SF levels, which may be related to the onset and progression of this disease.

关 键 词：尘肺 神经烯醇化酶 铁蛋白 

分 类 号：R135.2[医药卫生—劳动卫生]