多模式成像技术检测易损斑块  

Non-invasive multi-modality imaging techniques in detection of vulnerable plaques

作　　者：赵学诚[1] 赵全明[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科18病房,北京100029

出　　处：《中国医学影像技术》2013年第7期1218-1221,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金项目(30972810;81071196);北京自然科学基金项目(7132078)

摘　　要：易损斑块的早期检测对预防其严重并发症(如急性冠状动脉综合征)至关重要。斑块的易损性主要取决于斑块的炎症状态。因此迫切需要一种既能反映斑块形态学特征又能体现斑块炎症程度的影像学手段。PET/CT和PET/MRI作为多模式成像技术,能够评价动脉粥样斑块炎症程度。本文就CT、MRI、PET/CT、PET/MRI检测冠状动脉粥样硬化易损斑块的研究进展进行综述。Detection of vulnerable plaques on the early stage is of vital importance in the prevention of its dreadful compli- cations such as acute coronary syndrome. However, inflammatory cells and proteins play a key role in the progression of vulnerable plaques. So clinically, there is an urgent need for a kind of multi-modality imaging strategy which can both re- flect the characteristics of plaque morphology and plaque inflammation degree. PET/CT and PET/MRI are promising strat- egies in this regard, especially combined with CT or MRI, which provide not only the morphological characteristics, but al- so the inflammatory state of the atheromatous plaques. The progresses of CT, MRI, PET/CT, PET/MRI for detection of vulnerable plaques were reviewed in this article.

关 键 词：斑块 动脉粥样硬化 正电子发射型体层摄影术 体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 磁共振成像 

分 类 号：R541[医药卫生—心血管疾病] R445[医药卫生—内科学]