外周免疫耐受机制的研究进展  

Progress in mechanisms of peripheral immunological tolerance

作　　者：伍仙凤[1] 盛德乔[1] 

机构地区：[1]三峡大学医学院,宜昌443002

出　　处：《免疫学杂志》2013年第8期710-714,719,共6页Immunological Journal

基　　金：国家自然科学基金资助项目(81172788)

摘　　要：在T细胞发育过程中,体内自身反应性T淋巴细胞在胸腺中会通过阴性选择而清除,少数自身反应性T淋巴细胞可逃避阴性选择到达外周淋巴器官。外周免疫耐受机制的作用是抑制及限制从胸腺中逃逸出来的成熟的自身反应性T淋巴细胞的活性。维持外周免疫耐受包括克隆清除、克隆无能、免疫忽视、Treg细胞的免疫抑制、耐受型DCs等多种机制。一旦外周免疫耐受被打破,外周的自身反应性T细胞会引发自身免疫反应,从而导致严重的自身免疫疾病。During the development of T lymphocytes, most of self-reactive T lymphocytes are deleted by negative selection in thymus, but there are still a few of them escaped to peripheral lymph organs. The function of peripheral immunological tolerance is to inhibit and restrict the reactivity of self-reactive T lymphocytes escaped from thymus in the periphery. There are various mechanisms participate the maintenance of peripheral immunological tolerance, including clone deletion, clonal anergy, immunological ignorance, immunosuppression of Treg, tolerogenic DCs, etc. Once peripheral immunological tolerance is broken down, it will cause autoimmune reaction and severe autoimmunity.

关 键 词：外周免疫耐受 克隆清除 克隆无能 TREGS 耐受型DCs 

分 类 号：R392.11[医药卫生—免疫学]