晚卵泡期血清孕酮升高对卵裂期胚胎移植的临床妊娠结局的影响  

Effects of Progesterone Elevation in Late Follicular Phase on the Pregnancy Outcomes of Embryo Transfer in Cleavage Stage

作　　者：李蕊蕊[1] 郭艺红[1] 孙莹璞[1] 苏迎春[1] 陈帆[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《实用妇产科杂志》2013年第7期533-536,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨晚卵泡期血清孕酮(P)升高对卵裂期胚胎移植的临床妊娠结局的影响。方法:我院2010年1月至2011年12期行体外受精-胚胎移植(IVF-ET)的卵裂期胚胎移植2345个周期,根据注射人绒毛膜促性腺激素(HCG)日P水平分为P正常组(P≤4.77nmol/L)2045个周期,P升高组(P>4.77nmol/L)300个周期,比较两组的IVF-ET的临床妊娠结局。结果:P正常组与P升高组获卵数分别为10.72±4.67、12.94±5.30;临床妊娠率分别为55.35%(1132/2045)、46.67%(140/300);异位妊娠率分别为2.83%(32/1132)、7.86%(11/140),差异均有统计学意义(P<0.01)。P正常组与P升高组的受精率、胚胎种植率及早期流产率差异均无统计学意义(P>0.05)。结论:晚卵泡期P升高可降低卵裂期胚胎移植的临床妊娠率,并增加其异位妊娠风险。Objective：To explore the effects of progesterone（P） elevation at the end of follicular phase on the pregnancy outcomes of day 3 embryo transfer. Methods：2345 in vitro fertilization and embryo transfer （IVF-ET） cycles including day 3 embryo transfer cycles performed in our Reproductive Center from January 2010 to December 2011 were retrospectively analyzed. According to the serous P level on the day of human chorionic gonadotrophin （HCG） administration, day 3 embryo transfer cycles were respectively divided into normal P level group （P≤4.77nmol/L,2045 cycles） and P elevation group （P 〉4.77nmol/L,300cycles）. Compare the clinical pregnant outcome between groups. Results： The oocytes retrieved in normal P level group and P elevation group were 10. 72 ±4. 67 and 12.94 ±5.30, respectively;the clinical pregnancy rates were 55.35% （1132/2045） and 46.67% （140/300）, respectively; and the ectopic pregnancy rates were 2.83% （32/1132） and 7.86% （ 11/140）, respectively, all with significant difference （ P 〈 0.01 ）. There were no statistical differences in fetilization rates,embryos cleavage rates and early abortion rates between the two groups（ P 〈 0.05）. Conclusions： Elevated progesterone at the end of the follicular phase can reduce the clinic pregnancy rate and increase ectopic pregnancy risk in D3 embryo transfer.

关 键 词：体外受精-胚胎移植 晚卵泡期 孕酮 卵裂期 妊娠结局 

分 类 号：R715.2[医药卫生—妇产科学]