Xp11.2易位相关性肾细胞癌的临床特点  

Clinical features of renal cell carcinoma associated with Xp11.2 translocation

作　　者：王昌[1] 李丽[2] 董彩莉[3] 刘承[1] 王坤[1] 刘海南[1] 范医东[1] 

机构地区：[1]山东大学齐鲁医院泌尿外科,济南250012 [2]山东大学齐鲁医院病理科,济南250012 [3]山东大学齐鲁医院手术室,济南250012

出　　处：《山东大学学报（医学版）》2013年第7期79-83,共5页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金(81272814)

摘　　要：目的总结Xp11.2易位相关性肾细胞癌的临床特点,探讨Xp11.2易位相关性肾细胞癌的诊断治疗思路。方法收集山东大学齐鲁医院泌尿外科2011～2012年3例Xp11.2易位相关性肾细胞癌患者的临床及随访资料,对术后标本处理后进行分析总结,并结合文献资料复习。结果 3例患者中,2例因无痛性肉眼血尿检查发现,1例因健康查体发现。3例患者CT扫描结果示肾脏肿块平均4 cm×5 cm,肿块内均可见点状钙化,增强扫描后呈不均匀强化。免疫组织化学和RT-PCR均证实为Xp11.2易位相关性肾细胞癌。结论 Xp11.2易位相关性肾细胞癌的有效治疗方案仍在研究探索中。Objective To sunamarize the clinical features of renal cell carcinoma associated with Xpl 1.2 translocation, and to explore the approach of its diagnosis and treatment. Methods The clinical and follow-up data of three cases of renal cell carcinoma associated with Xpl 1.2 translocations were collected in the department of urology, Qilu Hospital during 2011 and 2012. The surgical specimens were analyzed and the relevant literature were reviewed. Results Two of the three cases were found after painless gross hematuria and the other was found by physical examination. The aver- age size of all the three renal tumors was 4 cm × 5 cm, calcification spots were found in CT scan, and the tumors were strengthened unevenly by contrast mediums. The genetic feature of all three cases was confirmed by immuneohistochem- istry and RT-PCR, which belonged to renal cell carcinoma associated with Xpl 1.2 translocation. Conclusion The effective treatment of renal cell carcinoma associated with Xpl 1.2 translocation is still in the study.

关 键 词：肾肿瘤 Xp11 2易位 TFE3基因 融合蛋白 

分 类 号：R692.9[医药卫生—泌尿科学]