尖锐湿疣组织中蛋白酪氨酸磷酸酶-1和表皮生长因子受体的表达  

Expression of SHP-1 and EGFR in condyloma acuminatum tissues

作　　者：肖汉龙[1,2] 陶娟[1] 刘辉峰[1] 安湘杰[1] 王育珏[1] 涂亚庭[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,湖北武汉430022 [2]武汉市武警湖北总队医院皮肤科,430061

出　　处：《临床皮肤科杂志》2013年第8期458-460,共3页Journal of Clinical Dermatology

摘　　要：目的:探讨蛋白酪氨酸磷酸酶-1(SHP-1)和表皮生长因子受体(EGFR)在尖锐湿疣组织中的表达及意义。方法:采用免疫组化SP法检测30例尖锐湿疣患者组织和20例正常人包皮组织中SHP-1和EGFR的表达。结果:①尖锐湿疣组织中SHP-1的阳性表达率与正常对照组相比差异无统计学意义(P>0.05);但阳性表达强度显著低于正常对照组(P<0.01);②尖锐湿疣组织中EGFR的阳性表达强度显著高于正常对照组(P<0.01);③尖锐湿疣组织中SHP-1和EGFR的表达呈负相关。结论:SHP-1和EGFR在尖锐湿疣组织中异常表达,可能与尖锐湿疣细胞的过度增殖有关。Objective： To investigate the expression of src-homology domain 2 containing protein tyrosine phosphatase-1 （SHP-1） and epidermal growth factor receptor （EGFR） in condyloma acuminatum （CA） tissues. Methods： Immunohistochemical staining for SHP-1 and EGFR was carried out in specimens from 30 cases of CA and 20 normal foreskin tissues. Results： （1）There was no significant difference in the positive rate of SHP-1 staining between CA and normal controls（P〉0.05） but the expression intensity of SHP-1 was significantly lower in CA than in normal controls（P〈0.01）. （2）The expression intensi- ty of EGFR was significantly higher in CA than in normal controls（P〈 0.01）. （3）The expression of SHP-1 was negatively correlated with that of EGFR in CA（P〈 0.01）. Conclusions： There is an abnormal expression of SHP-1 and EGFR in CA tissues which can be associated with the hyper-proliferation of CA cells.

关 键 词：尖锐湿疣 蛋白酪氨酸磷酸酶-1 表皮生长因子受体 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]