随机、双盲、自身对照试验评估滋养沐浴乳对冬季小腿皮肤干燥症的作用  

Effect of emollient body wash on leg xerosis in winter:a randomized,double-blinded, self-controlled study

作　　者：陈国红[1] 孙晓冬[2] 张丽[1] 白英龙[3] 齐瑞群[1] 安倩[1] 刘哲[1] 吕娅妮[1] 许雅琴[1] 潘君位[1] 马艳[1] 秦秀美[1] 高兴华[1] 

机构地区：[1]中国医科大学附属第一医院皮肤科,辽宁沈阳110001 [2]沈阳市第七人民医院皮肤科,辽宁沈阳110003 [3]中国医科大学公共卫生学院,辽宁沈阳110001

出　　处：《临床皮肤科杂志》2013年第8期461-463,共3页Journal of Clinical Dermatology

基　　金：辽宁省科学技术计划项目(课题号:2009225011-1)资助项目

摘　　要：目的:评价具有滋养成分的沐浴乳对中国北方寒冷季节小腿皮肤干燥症的作用及安全性。方法:采用随机、双盲、自身对照方法,对36例受试者外用滋养沐浴乳,并观察26 d。结果:试验组瘙痒程度低于对照组,试验试剂对皮肤干燥程度影响小于对照试剂,差异有统计学意义;试验组角质层含水量下降显著延迟;不良反应发生率低,差异有统计学意义。结论:滋养沐浴乳对缓解皮肤干燥症的部分症状指标有效,且安全性较高。Objective： To evaluate the clinical efficacy and safety of emollient body wash in treatment of leg xerosis in winter. Methods： A randomized, double-blinded, self-controlled trial was performed on 36 patients for 26 days. Results： The itching degree and the degree of dryness were reduced significantly in study group than in control group. Treatment with e- mollient body wash significantly delayed the reduction of stratum corneum hydration and lowered the rate of the adverse reactions. Conclusion： The emollient body wash is effective and safe in improving leg xerosis in winter.

关 键 词：干燥症 滋养 保湿 清洗剂 皮肤屏障功能 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]