MicroRNA及其靶基因的时空特异性与动态变化  

Time and Space Specificity and Dynamic Change of microRNA and Its Targets

作　　者：李洁[1] 秦性良[1] 邵宁生[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《生物化学与生物物理进展》2013年第7期617-626,共10页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)(2011CB811300;2010CB912801);国家自然科学基金(31100569;30971630)资助项目~~

摘　　要：MicroRNA(miRNA)是一类广泛存在于动植物中大小约22nt的内源单链非编码小RNA分子,通常在转录后水平负调控其靶基因的表达,在机体生命活动的各个过程中(如细胞增殖和分化、凋亡、疾病的发生发展等)发挥着重要的调节作用.越来越多的研究表明,miRNA的表达具有时序特异性和组织特异性.每种miRNA针对的数个甚至上百个潜在靶基因,在不同的细胞或同一细胞的不同状态下是否能发挥功能性靶标的作用也有所不同.这些研究结果不但说明miRNA及其靶标具有时空动态变化的特性,而且也提示miRNA在机体内发挥作用的复杂性.本文就miRNA及其靶标时空动态变化的相关研究进展做一综述,期望对深入了解miRNA的功能提供新的思路.MicroRNA（miRNA） are endogenous -22 nt non- coding small RNAs broadly expressed in plants and mammalians. MiRNAs are involved in the negative regulation of gene expression through the targeting of mRNAs during the process and activity of life such as cell proliferation and differentiation, apoptosis as well as the development of diseases. Recently, numerous studies have demonstrated that the expression of miRNA is of time and tissue specificity. It has been predicted that each miRNA may target more than one or hundreds of mRNAs. In addition, the functional targets ofmiRNAs may be different in different cells or the different states of the same cell. All these results suggested that miRNA and its functional targets may be dynamically variable with the time and space. MiRNAs may play complex roles in human body. In this paper the dynamic change of miRNA and its targets has been reviewed and it may provide new idea for the study ofmiRNAs.

关 键 词：MICRORNA 靶基因 时空特异性 动态变化 

分 类 号：Q71[生物学—分子生物学]