应用数据挖掘技术研究中医药治疗再生障碍性贫血的组方规律  

Study on Composing Prescription Laws of Treating Aplastic Anemia by Chinese Medicine Using Applying Data Mining Technique

作　　者：向阳[1] 于景伟[2] 成玉斌[1] 李海霞[1] 常晓慧[1] 周大伟[1] 孙锋[1] 方永光[1] 

机构地区：[1]中国人民解放军第210医院中医血液科,辽宁大连116021 [2]哈尔滨学院计算机系,哈尔滨150086

出　　处：《中国中西医结合杂志》2013年第7期906-910,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.81072752)

摘　　要：目的探讨中医药治疗再生障碍性贫血(aplasticanemia,AA)的组方规律。方法应用文献检索方法检索1979—2009年在中国知网(CNKI)、维普资讯网(VIP)、万方数据知识服务平台收录的有关中医药治疗AA的文献;应用计算机数据库技术建立相关中药特征数据库;应用数据挖掘(data mining,DM)技术分析中药复方的药物归类、用药频次和关联程度。结果筛选出相关文献311篇,收录方剂677首,涉及中药254味,其中补虚药69味、清热药42味、活血化瘀药20味、止血药16味、解表药16味,位居前5位;254味中药的用药频次达7547次,黄芪、生地黄、鸡血藤、仙鹤草、柴胡的用药频次分别为379、248、167、85、13,分别位列补虚药、清热药、活血化瘀药、止血药和解表药之首;含12味、10味及11味中药的方剂数量位列前3位;黄芪、当归两药的方剂覆盖率达60%,由此确立了益气养血、补肾助阳、滋阴补肾和补肾填精、益气养血4个核心药物群;总结出益气养血,补助肾阳,滋阴补肾,健脾和胃,补血活血和清热解毒、凉血止血6个可能的组方原则。结论应用DM技术发现了中医药治疗AA的基础核心药物为黄芪、当归,确立的4个核心药物群符合现代中医对AA病机的认识,总结的6个组方原则揭示了中医药治疗AA的用药规律。Objective To explore composing prescription laws of treating aplastic anemia （AA） by Chinese medicine （CM）. Methods The literatures on treating AA by CM were recruited from various medical periodicals at home from 1979 to 2009 including China National Knowledge Infrastrueture （CNKI）, VIP information network, and Wangfang data knowledge service platform. The database correla- ted to CM features was established using the technique of computer data bank. The data mining （DM） technique was applied to analyze drugs sorts, frequency of drug application, and association degree. Re- sults Three hundred and eleven pertinent literatures including 677 prescriptions and 254 Chinese herbs （CHs were screened. There were 69 CHs for invigorating deficiency, 42 for heat clearing, 20 for promo- ting blood circulation and removing blood stasis, 16 for arresting bleeding, and 16 for relieving exterior synerome, which occupied the top 5. The frequency of drug application of 254 CHs amounted to 7 547, in which the frequencys of drug application of Mongolian milkvetch root, Rehmannia root, Suberect spatholobus stem, Hairyvein agrimonia herb, and Chinese thorowax root were 379,248,167,85, and 13 respectively, and they occupied the first place of CHs for invigorating deficiency, heat clearing, promoting blood circulation and removing blood stasis, arresting bleeding, and relieving exterior synerome, respectively. The number of the prescriptions containing 12, 10, and 11 CHs was occupied the top 3. The coverage rate of the prescription including Mongolian milkvetch root and Chinese angelica was 60%, and thus 4 core drugs groups were established covering invigorating qi and enriching the blood, reinforcing Shen and supporting yang, replenishing yin to tonify Shen, tonifying Shen to replenish essence, and in- vigorating qi and enriching blood respectively. Summarized were six potential composing prescription laws covering invigorating qi and enriching blood, reinforcing Shen and supporting yang, replenishing yin to tonify

关 键 词：再生障碍性贫血 中医药治疗 组方 数据挖掘 

分 类 号：R259[医药卫生—中西医结合]