纺锤体检测点与胚胎非整倍体的关系  

Relationship between spindle checkpoint and embryo aneuploidy

作　　者：刘琨[1] 任育宏[1] 张学红[1] 薛石龙[1] 

机构地区：[1]兰州大学第一医院生殖医学专科医院,甘肃兰州730000

出　　处：《生殖医学杂志》2013年第7期547-550,共4页Journal of Reproductive Medicine

基　　金：兰州大学交叉学科青年创新研究基金(项目编号:LZUJC200923);兰州大学中央高校基本科研业务费专项资金资助(项目编号:lzujbky-2009-146)

摘　　要：纺锤体检测点对有丝分裂和减数分裂中期与后期转换过程中纺锤体的形成起着非常重要的作用,其组成成分最初是在发芽的酵母中通过基因检测证实,此后发展到人,大量细胞中均发现某些检测蛋白。研究表明,纺锤体检测系统参与雌性哺乳动物减数分裂的调控,防止胚胎非整倍体的发生。本文阐述在有丝分裂和减数分裂中关于纺锤体检测点的研究进展,了解检测信号传导通路及其在减数分裂中防止染色体异常的作用,进一步探讨胚胎非整倍体发生的原因。Spindle checkpoint plays a very important role on the mitotic and meiotic metaphase and anaphase transition process in which spindle is developed. Its composition is confirmed initially in budding yeast by genetic testing, and then some detecting proteins were found in human cells. It is found that spindle detection system is involved in the regulation of mammalian female meiosis and prevents the occurrence of embryo aneuploidy. Therefore, this paper elaborated the research progress of spindle checkpoint development in mitosis and meiosis, learning more about the detection signal transduction pathway and its role in prevention of abnormal chromosome in meiosis, to further explore the causes of embryo aneuploidy.

关 键 词：非整倍体 纺锤体 检测点 减数分裂 胚胎 

分 类 号：R4[医药卫生—临床医学]