糖尿病性白内障超声乳化术后玻璃酸钠联合重组牛碱性成纤维细胞生长因子治疗干眼症研究  

Clinical study on the effect of combination therapy of sodium hyaluronate and recombinant bovine basic fibroblast growth factor after phacoemulsification in diabetics

作　　者：许薇琦[1] 费新峰[1] 张静[1] 丁文珠[1] 张剑虹 

机构地区：[1]上海市第一人民医院分院,上海200081 [2]上海交通大学附属第一人民医院

出　　处：《中国实用眼科杂志》2013年第7期844-848,共5页Chinese Journal of Practical Ophthalmology

基　　金：上海市虹口区卫生局课题（1004-08）

摘　　要：目的观察单纯玻璃酸钠治疗与玻璃酸钠联合重组牛碱性成纤维细胞生长因子治疗对糖尿病患者白内障术后泪膜的动态变化。方法临床病例治疗对照研究。对2011年5月至2012年5月在上海市第一人民医院分院眼科就诊的白内障超声乳化术的糖尿病患者86例125只眼，分为对照组（A组45只眼）、玻璃酸钠治疗组（B组43只眼）和联合治疗组（C组37只眼）。在术前、术后1天、术后1周、术后1月进行主观干眼感觉、泪膜破裂时间（BUT）、基础泪液分泌试验（SIt）及角膜荧光素染色（FL）检查。结果3组术后与术前比较，干眼主观症状增多、BUT明显缩短、SIt和FL明显增多。术后1月，A组干眼主观症状、BUT和FL与术前相比仍具有统计学意义（P〈0．01）。与术前相比，B组sIt和FL术后1周、干眼主观症状和BUT术后1月接近术前水平。C组术后1周干眼主观症状、BUT、Sit和FL接近术前水平（P〉0．05）。结论糖尿病患者行白内障超声乳化手术后早期使用玻璃酸钠与重组牛碱性成纤维细胞生长因子联合治疗，更有利于改善症状、恢复泪膜稳定性。Objective To study the efficacy of the combined treatment with sodium hyaluronate （HA） and recombinant bovine basic fibroblast growth factor （r-bFGF） for II-diabetic patients after phacoemulsification. Methods A total of 86 II-diabetic patients undergoing phacoemulsification were randomized divided into control group （group A, 45 eyes with conventional therapy）, single treat- ment group （group B, 43 eyes with conventional therapy and HA） and combined treatment group （group C, 37 eyes with conventional therapy, HA and r-bFGF）. Subjective symptoms, tear film break-up time （BUT）, Schirmer I test （Sit） and corneal fluorescein staining （FL） were measured pre- operatively and 1 day, 1 week and 1 month postoperatively. Results In all groups, the BUT re- duced greatly, Sit value and FL increased significantly after phacoemulsification. Compared with pre- operations in group A, subjective complains of dry eye increased and the BUT reduced in 1 day, 1 week and 1 month postoperatively. So did FL. Sit value returned at postoperative value at 1 month after operations. In group B, Sit value and FL returned to postoperative value at postoperative 1 week, so did subjective complains of dry eye and BUT at postoperative 1 month. There were no sig- nificant differences in subjective complains of dry eye, BUT, Sit and FL in group C in 1 week af- ter phacoemulsification. Conclusions It can be more effective to relieve the dry eye symptoms forII-diabetic patients to use combined treatment with HA and r-bFGF at early stage after phacoemulsifi- cation.

关 键 词：糖尿病 白内障超声乳化吸除术后 泪膜 玻璃酸钠 重组牛碱性成纤维细胞生长 因子 

分 类 号：R977[医药卫生—药品]