小剂量十一酸睾酮联合他达拉非治疗LOH伴ED的临床研究  

Low-dose testosterone undecanoate capsules combined with tadalafil for late-onset hypogonadism accompanied with ED

作　　者：李广裕[1] 梁季鸿[1] 蒙志彬[1] 黄存超[1] 梁世坤[1] 韦国强[1] 申树林[1] 朱春晖[1] 张迅[1] 宋卫儒[1] 

机构地区：[1]广西医科大学第一附属医院男科,广西南宁530021

出　　处：《中华男科学杂志》2013年第7期630-633,共4页National Journal of Andrology

摘　　要：目的:观察小剂量十一酸睾酮联合他达拉非治疗迟发性性腺功能低下(LOH)伴勃起功能障碍(ED)患者的临床疗效。方法:符合纳入标准的90例LOH伴ED患者随机分为对照组(他达拉非治疗)、联合组(小剂量十一酸睾酮+他达拉非治疗),分别比较组内和组间治疗前后的LOH症状、IIEF-5评分、SEP评分、总睾酮(TT)、游离睾酮(FT)、PSA、前列腺体积等变化。结果:联合组治疗后IIEF-5评分、SEP评分、TT、FT分别为(20.6±3.8)分、(4.02±1.08)分、(15.4±3.4)nmol/L、(0.391±0.062)nmol/L,均显著高于治疗前[(15.7±3.9)分、(1.49±0.82)分、(10.1±1.2)nmol/L、(0.200±0.045)nmol/L,P均<0.01],且改善明显优于对照组治疗后[(8.6±3.6)分、(3.50±1.21)分、(10.2±1.2)nmol/L、(0.210±0.051)nmol/L,P均<0.01]。结论:小剂量十一酸睾酮联合他达拉非治疗LOH伴ED患者疗效确切,未见明显的补充雄激素带来的不良反应。Objective： To observe the clinical effect of low-dose testosterone undecanoate capsules combined with tadalafil on late-onset hypogonadism （LOH） accompanied with ED. Methods ： Ninety cases of LOH accompanied with ED who met the inclusion criteria were randomly divided into a control group and a combination therapy group, the former treated with tadalalil and the latter with low-dose testosterone undecanoate capsules combined with tadalafil. The LOH symptoms, IIEF-5 scores, sexual encounter profile （SEP） scores, prostate volumes, and the levels of total testosterone （TF）, free testosterone （FT） and prostatic specific antigen （PSA） were recorded and compared between the two groups before and after treatment. Results ： The IIEF-5 and SEP scores and the TF and FT levels were 20.6 ± 3.8, 4.02 ± 1.08, （ 15.4 ± 3.4） nmol/L and （0.391 ± 0. 062） nmol/L, respectively, in the combina- tion therapy group after treatment, significantly higher both than 15.7 ± 3.9, 1.49 ± 0.82, （ 10. 1 ± 1.2） nmol/L and （0. 200 ± 0. 045 ） nmold L before treatment （ P 〈 0. 01 ） and thali 8.6 ± 3.6,3.50 ± 1.21, （ 10. 2 ± 1.2） nmoVL and （0. 210 ± 0. 051 ） nmol/L in the control group after treatment （ P 〈 0. 01 ）. Conclusion ： Low-dose testosterone undecanoate capsules combined with tadalafilhas a definite clinical effect and no obvious adverse reactions in the treatment of LOH accompanied with ED.

关 键 词：十一酸睾酮 他达拉非 迟发性性腺功能低下 勃起功能障碍 

分 类 号：R698.1[医药卫生—泌尿科学]