棘白菌素类药物对念珠菌的耐药机制及抗真菌活性检测的研究进展  

Advance of resistance mechanisms of echinocandins against Candida and antifungal activity in vitro

作　　者：苏建荣[1] 丁秀荣[1] 

机构地区：[1]首都医科大学附属北京友谊医院临床检验中心,100050

出　　处：《中华检验医学杂志》2013年第7期588-591,共4页Chinese Journal of Laboratory Medicine

摘　　要：棘白菌素类作为新一代抗真菌药物，对念珠菌表现出良好的杀菌活性，但随着应用时间的延长和应用范同的扩大，也出现由不同的耐药机制导致的抗念珠菌活性降低。人类的血清、体外培养温度和培养介质的pH值等因素对该类药物抗念珠菌活性检测结果有影响，矛盾生长现象有其特殊性，有待进一步研究。该药物在我国的临床应用时间较短，临床耐药情况报告不全面。因此，研究棘白菌素耐药流行率和不同状态下该药物的杀菌活性有重要的临床意义。Although echinocandins, a new generation of antifungal drugs, shows good fungicidal activity against distinct species of Candida, with the extending usage, the activity of echinocandins is gradually to decline, which is caused by different resistance mechanisms. Also, a number of factors may influenc.e its results of susceptibility in vitro （ e. g. , human serum, culture temperature in vitro, the pH of the culture medium, and others）. Paradoxical effect of echinocandins has its own characteristics and need a further study. In China, there are a few reports about the instances of drug resistance because of the limited clinic application. The study on the echinocandins in prevalence rate of dn^g resistance and antifungal activity under different status has important clinical significance.

关 键 词：棘白菌素类 矛盾生长现象 抗药性 真菌 

分 类 号：R978.5[医药卫生—药品]