2型糖尿病大血管病变患者血清IL-17水平变化及意义  

The expression levels of serum interleukin-17 in type 2 diabetes with macroangiopathy

作　　者：楼旭丹[1] 汪海东[1] 陈芳[1] 夏世金[2] 孙皎[1] 

机构地区：[1]复旦大学附属华东医院内分泌科,上海200040 [2]上海市老年医学研究所

出　　处：《中国老年学杂志》2013年第13期3024-3026,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金面上项目(No.31171129);上海市科委科技发展基金基础研究重点课题(No.10JC1404800)

摘　　要：目的探讨2型糖尿病(T2DM)大血管病变患者血清IL-17的表达水平及意义。方法 162例T2DM患者,根据是否合并大血管病变,分为大血管病变组90例和无血管病变组72例,另选同期健康查体者68例作为正常对照组。采用酶联免疫吸附法(ELISA)测定三组人群空腹静脉血中IL-17水平,统计IL-17与各临床指标间的关系,分析其影响因素。同时,根据T2DM大血管病变患者颈动脉内膜中层厚度,探讨有无颈动脉增厚对IL-17水平的影响。结果 T2DM合并大血管病变组血清IL-17水平显著高于无血管病变组及正常对照组,T2DM无大血管病变组高于正常对照组(P<0.01)。T2DM大血管病变患者中,颈动脉增厚组IL-17水平明显高于无颈动脉增厚组(P<0.05)。在大血管病变组IL-17与BMI、2 h PG、hs-CRP、TG、LDL-C呈正相关,而与HDL-C呈负相关。多元逐步回归分析显示IL-17、hs-CRP和LDL-C是T2DM大血管病变的主要影响因素。结论T2DM大血管病变组和颈动脉增厚组血清IL-17表达均增高,提示IL-17参与糖尿病大血管病变的炎症反应过程。IL-17可能是T2DM大血管病变的独立危险因素,在糖尿病大血管病变发生、发展中发挥重要作用。Objective To study the expression levels of serum interleukin-17（IL-17） in type 2 diabetes mellitus（T2DM） with macroangiopathy,and to carry out the correlation analysis between these two factors.Methods A total of 162 patients diagnosed of T2DM were divided into two groups according to the macrovascular complications,90 cases with macroangiopathy and 72 cases without macroangiopathy,another 68 healthy persons were enrolled in control group.Serum level of IL-17 was measured by enzyme linked immunosorbent assay（ELISA）,the relationship between IL-17 and other impact factors was statistically analyzed.Meanwhile,according to the presence or absence of the thickening of carotid intima-media thickness（IMT）,T2DM macroangiopathy patients were then assigned into another two groups to compare the IL-17 levels.Results The levels of serum IL-17 in T2DM with and without macroangiopathy groups were significantly higher than those of control group,and the differences from those of T2DM groups were also statistically significant（P0.05）.The level of IL-17 in T2DM with carotid thickening group was largely increased compared with that of non-thickening group（P0.05）.In T2DM with macroangiopathy group,the level of IL-17 was positively correlated with BMI,2 h PG,hs-CRP,TG,LDL-C and negatively correlated with HDL-C.Stepwise regression analysis showed that IL-17,hs-CRP and HDL-C were the main factors for T2DM macroangiopathy.Conclusions The serum IL-17 expression levels of T2DM with macroangiopathy and carotid thickening groups are elevated,which suggest that IL-17 might be involved in the process of inflammatory response to diabetic macroangiopathy.IL-17 might be an independent risk factor for T2DM macroangiopathy,and play a vital role in the onset and development of diabetic vascular diseases.

关 键 词：IL-17 2型糖尿病 大血管病变 

分 类 号：R587.1[医药卫生—内分泌]