血小板浓缩物在骨关节病和运动损伤疾病中的应用  

Platelet Concentrate Therapy in the Osteoarthropathy and Sport Injury

作　　者：李晋 王文波 谢燕霞 阎影[1,2] 

机构地区：[1]干细胞与再生医学研究所中健医疗集团,北京100094 [2]密苏里大学堪萨斯医学院癌症研究所,堪萨斯64108

出　　处：《中国骨与关节杂志》2013年第7期407-413,共7页Chinese Journal of Bone and Joint

摘　　要：血小板浓缩物（PC1是外科使用多年的纤维蛋白凝胶技术衍化发展而来的新型制剂。最初用富集的血小板和血小板所含生长因子，激活形成纤维蛋白凝胶后，促进外科手术创口的愈合。血小板α颗粒中含有血小板源生长因子，血管内皮生长因子，Platelet concentrate （ PC ） for surgical use is an evolution of the fibrin glue technologies used since many years. The initial concept of these preparations was to concentrate platelets and their growth factors and activate it into a fibrin gel on a surgical site, in order to improve local healing. The platelets contain alpha granules that are rich in several growth factors, such as platelet-derived growth factor, vascular endothelial growth factor, transforming growth factor-[3, insulin-like growth factor, and epidermal growth factor, which play the essential roles in tissue healing and regeneration mechanisms. The relative ease of obtaining and preparation, convenience and applicability in the clinical setting, favorable safety profile and possible beneficial outcomes make PCs a new promising therapeutic approach for future regenerative therapy strategy. Numerous techniques of PC have been developed. The most common forms of autologous platelet concentrates： Platetet rich plasma （ PRP ） and platelet rich fibrin （ PRF ） have been introduced into various medical fields, including orthopedic surgery, plastic surgery, sports injury and other areas of regenerative medicine. More recently, developments in research of the regenerative effects of PC in a range of tissue types including bone, cartilage, tendon and muscle, as well as in the tissues of traumatic injury, have attracted interest in fields such as orthopedic and sport medicine. Many clinical studies suggested that the PC therapies may have benefits to osteoarthropathy such as osteoarthritis and necrosis of femoral head, and the conditions such as epicondylitis, ligament and muscle strains, and tears of rotator cuff, anterior cruciate ligament and Achilles tendon, as well as other sport related injuries. However, our understanding of the mechanisms of PCs in tissue repair and healing is still limited in basic research. There are also limited publications that provided convincing evidences of the efficacy of PCs therapy in the treatment of these

关 键 词：血小板浓缩物 运动损伤 骨关节病 血小板源生长因子 血管内皮生长因子 纤维蛋白凝胶 疾病 凝胶技术 

分 类 号：R684[医药卫生—骨科学] R318[医药卫生—外科学]