脐带间充质细胞生物学特性及应用研究  

Biological characteristics and applification of bilical cord mesenchymal cells

作　　者：肖娟[1] 姜晓蓉[1] 刘靖媛[1] 魏国梅[1] 高文勇[1] 陈琳[1,2,3,4] 黄红云[1,2,3] 

机构地区：[1]北京市虹天济神经科学研究院 [2]泰山医学院神经科学研究所 [3]北京康复中心神经外科 [4]清华大学医学院,北京100144

出　　处：《解剖科学进展》2013年第4期363-365,共3页Progress of Anatomical Sciences

基　　金：首都医学发展科研基金(No.2009-3229)

摘　　要：间充质细胞是来源于中胚层的一种能自我更新和具有多向分化潜能的成体干细胞,存在于全身结缔组织和器官中。间充质细胞呈典型的成纤维状,高表达间质细胞标志蛋白CD44,CD90和CD105,不表达造血系标志蛋白CD34和CD45。间充质细胞经诱导培养不仅能分化成骨细胞,软骨细胞,干细胞,心肌细胞等,也可以分化成多巴胺能神经元等。人脐带间充质细胞与其他来源的间充质细胞相比,具有来源广,免疫原性低,避免伦理学问题等诸多优点。因此,脐带间充质细胞作为临床细胞治疗和组织再生的一个理想来源而越来越受关注。Mesenchymal stem cells （MSCs） are a kind of prototypical adult stem cells with capacity for self- renewal and differentiation with a broad tissue distribution. MSCs have the capacity to differentiate into mesoderm- and nonmesoderm-derived tissues, especially the umbilical mesenchymal stem eells（UMSCs）. The human umbilical cord mesenchymal stem cells shape like typical fibroblast, overexpress interstitial cell marks CD44, CD90 and CD105, but not express hematopoietic system marks CD34 and CD45. UMSCs could differentiate into not only osteocytes, cartilage cells, hepatic cells and cardiac muscle cells in vitro, but also into dopaminergic neurons. Compared with the other sources of MSCs, UMSCs have a lot of advantages, such as broad source, nonimmune reaction and avoiding the problem of ethical. Therefore, UMSCs are an ideal source for the treatment and clinical cell regeneration. This review summarized recent studies in the biological characteristics and clinical study of umbilical MSCs.

关 键 词：间充质细胞 细胞生物学特性 人脐带 多向分化潜能 多巴胺能神经元 成体干细胞 应用 标志蛋白 

分 类 号：Q813.11[生物学—生物工程]