多奈哌齐干预老年轻度认知功能障碍的临床研究  

Clinical Study of Intervention in Mild Cognitive Impairment by Donepezil in Elderly Patients

作　　者：余琳玲[1] 胡红玲[2] 李珊[3] 邱伟文[1] 邬至平[1] 陈洁芳[1] 黄良通[1] 

机构地区：[1]丽水市中心医院神经内科,浙江丽水323000 [2]丽水市中心医院肌电图室,浙江丽水323000 [3]丽水市中心医院公共卫生科,浙江丽水323000

出　　处：《药物流行病学杂志》2013年第7期345-347,共3页Chinese Journal of Pharmacoepidemiology

基　　金：浙江省丽水市科技计划资助项目

摘　　要：目的:观察多奈哌齐早期干预老年轻度认知功能障碍患者的疗效及安全性。方法:60例轻度认知功能障碍(MCI)老年患者随机分成治疗组32例和对照组28例。2组患者均给予控制高危因素(高血压、糖尿病、高血脂等)治疗。治疗组在此基础上予盐酸多奈哌齐片5 mg,po qd,共12个月。治疗前后分别使用蒙特利尔认知评估量表(MoCA)及认知电位P_(300)评估疗效。结果:治疗组治疗前后MoCA评分、P_(300)潜伏期和波幅比较,差异有统计学意义(P<0.05);对照组无明显变化。组间比较,差异有统计学意义(P<0.05)。MoCA量表亚项比较,显示在延迟记忆方面,治疗组治疗前后及与对照组比较,差异均有统计学意义(P<0.05)。结论:多奈哌齐能有效改善老年MCI患者的认知功能。Objective：To Explore the efficacy of early intervention in mild cognitive impairment by donepezil in the elderly.Methods：60 elderly patients with mild cognitive impairment（MCI） were randomly divided into two groups,the treatment group of 32 patients with oral hydrochloride donepezil tablets 5 mg once a day,a total of 12 months and the controlled group of 28 patients.2 patients were given control of risk factors（hypertension,diabetes,high cholesterol,etc.） treatment.Before and after treatment,Montreal Cognitive Assessment（MoCA） and P300 were used to assess the efficacy. Results：Before and after the treatment,MoCA score and P300 latency and amplitude differences were statistically significant （P 0.05 ）.There was no significant change in the controlled group but the difference between the two groups were statistically significant（P 0.05）.MoCA scale sub-item comparison and delayed memory were compared between the two groups before and after treatment.The differences were statistically significant（P 0.05）.Conclusion：Donepezil could improve the cognitive function in elderly patients with MCI.

关 键 词：轻度认知功能障碍 多奈哌齐 蒙特利尔认知评估量表 认知电位P300 

分 类 号：R971.92[医药卫生—药品]