甲钴胺联合依帕司他治疗糖尿病周围神经病变疗效观察  

Efficacy Analysis on Treatment of Diabetic Peripheral Neuropathy By Mecobalamin and Epalrestat

作　　者：张春驰[1] 贺昕[1] 董艳娟[1] 何跃[1] 

机构地区：[1]北京军区总医院干三科,北京100700

出　　处：《现代仪器与医疗》2013年第4期31-33,45,共4页Modern Instruments & Medical Treatment

摘　　要：目的采用甲钴胺联合依帕司他对糖尿病周围神经病变进行治疗,观察其临床疗效。方法 78例糖尿病周围神经病变(DPN)患者随机分为2组,治疗组和对照组各39例,2组患者均给予基础治疗,同时对照组采用甲钴胺对DNP治疗,治疗组在甲钴胺治疗的基础上加用依帕司他,2组疗程均为3个月。根据2组治疗前后神经症状、神经反射、感觉功能等方面分析,比较临床疗效。结果 2组患者治疗前后其运动神经肌电图传导速度和感觉神经肌电图传导速度比较,差异均具有显著性意义(P<0.05);治疗组和对照组总有效率分别为97.4%和71.8%,差异均具有显著性意义(P<0.01)。结论甲钴胺与依帕司他联合应用可有效治疗糖尿病周围神经病变,疗效满意,值得临床广泛推荐使用。Objective To investigate the efficacy of the clinical treatment of diabetic peripheral neuropathy（DPN） by mecobalamin and epalrestat.Methods 78 DPN patients were randomly divided into two groups,each one has 39 patients.The control group which treated with mecobalamin for 3 months and the treatment group which treated with mecobalamin and epalrestat as long as the control group were given basic treatment.The efficacy of clinical treatment were evaluated by the neurological symptoms,neural reflex and sensory functions.Results It is significant different compared to motor conduction velocity and sensory conduction velocity of the median nerve and the peroneal nerve（p0.05）.And the total efficiency of the treatment group and control group were 97.4% and 71.8%,respectively.It is significant different between the treatment group and the control group（p0.01）.Conclusions It is effective drugs with mecobalamin and epalrestat in treatment of DPN,and they are worthy to be recommended.

关 键 词：糖尿病周围神经病变 甲钴胺 依帕司他 临床疗效 

分 类 号：R587.2[医药卫生—内分泌]