糖化血红蛋白、尿微量清蛋白与β2微球蛋白检测在糖尿病早期肾损害中临床意义  

The clinical significance of detection of the level of blood HbA1c,urine mAlband β2MG in the early renal damage of DM

作　　者：王海英[1] 

机构地区：[1]北京军区总医院检验科,北京100700

出　　处：《现代仪器与医疗》2013年第4期56-57,61,共3页Modern Instruments & Medical Treatment

摘　　要：目的研究糖化血红蛋白(HbA1c)、随机尿微量清蛋白(mALB)与尿β2微球蛋白(β2MG)这3种指标监测在糖尿病(DM)早期肾损害中的作用。方法对糖尿病肾病组(DN)、单纯糖尿病组(DM)、对照组均采用高效液相色谱法测定糖化血红蛋白,采用透射比浊法检测β2MG及尿微量清蛋白。结果 DM组与对照组相比,前述3种指标的差异具有统计学意义(P<0.05),在DN组中,HbA1c、mALB及β2MG水平均显著高于对照组和DM组,其差异有高度统计学意义(P<0.01)。结论 HbA1c、mALB、β2MG 3个指标用来判断DM早期肾损害敏感而且可靠,灵敏度高,费用低廉,能够准确评估患者的病情发展程度。Objective To study clinical significance of decting the levels of HbA1c,mALB andβ2MG in the DM patients.Methods The innunoturbidimetry mothod was chosen to measure the level of mALB and β2MG,and the enzyme method was applied to measure the level of HbA1c.Results The former 3 indices showed statistical difference by comparing the DM group with the control group,P0.05.While the former 3 indices were higher than the other 2 groups,with significant statistical differences,P0.01.Conclusion BloodHbA1c,urine mAlb and β2MG of DM patients is relatively sensitive and reliable signals on the monitoring of early renal damage of DM.They can also be good biochemical markers for monitoring the development of DM and its treatment.

关 键 词：糖化血红蛋白 尿微量清蛋白 Β2微球蛋白 糖尿病 肾损害 

分 类 号：R587.1[医药卫生—内分泌]