隔药灸脐法对脾虚型肠易激综合征患者脑肠肽的影响  

Effect of herb-partitioned moxibustion at navel on serum ghrelin of irritable bowel syndrome patients with spleen deficiency pattern

作　　者：刘骁[1] 郭刚[2] 马玉侠[1] 刘存志[3] 高树中[1] 

机构地区：[1]山东中医药大学 [2]山东大学齐鲁医院,山东济南250012 [3]首都医科大学附属北京中医医院,北京100010

出　　处：《山东中医药大学学报》2013年第4期289-291,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973)课题(编号:2007CB512703);国家自然基金面上项目(编号:30973789)

摘　　要：目的:探讨隔药灸脐法对脾虚型肠易激综合征(IBS)血清脑肠肽含量的影响。方法:210例确诊患者随机分为隔药灸脐组(75例)、隔淀粉灸脐组(75例)和西药组(60例),治疗1疗程(4周)。治疗前后采用酶标免疫吸附测定法检测患者血清P物质(SP)、血管活性肠肽(VIP)和5-羟色胺(5-HT)的含量。结果:治疗后隔药灸脐组血清SP、VIP和5-HT含量均显著下降,与治疗前比较有显著性差异(P<0.05),但各组间治疗后比较无显著性差异(P>0.05)。结论:隔药灸脐通过降低IBS患者血清SP、VIP和5-HT含量发挥治疗作用。Objective：To explore the effect of herb-partitioned moxibustion at navel（Shenque,CV8） on serum ghrelin in irritable bowel syndrome（IBS） patients with spleen deficiency pattern.Methods：Total 210 patients were randomly assigned into 3 groups.One group was treated with herb-partitioned moxibustion at the navel（n=75）,the second group was treated with farina-partitioned moxibustion at the navel（n=75） and the third group was treated with western medicine（n=60）.All patients were treated for 4 weeks.The content of serum substance P（SP）,vascoactive intestinal peptide（VIP） and 5-hydroxytryptamine（5-HT） were detected by ELISA before and after treatment.Results：After treatment,the content of serum SP,VIP and 5-HT of herb-partitioned moxibustion group reduced,compared with those before treatment,there were significant difference（P 0.05）.However,there were no significant differences of serum SP,VIP and 5-HT between the three groups.Conclusion：Herb-partitioned moxibustion at navel could reduce the content of serum SP,VIP and 5-HT and improve the bowel function of IBS patients.

关 键 词：肠易激综合征 隔药灸脐 P物质 血管活性肠肽 5-羟色胺 临床研究 

分 类 号：R245.81[医药卫生—针灸推拿学] R259.744[医药卫生—中医临床基础]