硫酸氢氯吡格雷与阿司匹林联用致血尿  

Hematuria due to concomitant use of clopidogrel hydrogen sulfate and aspirin

作　　者：韩毓博[1] 程指民 李湘晖[1] 

机构地区：[1]哈尔滨医科大学附属第二医院药学部,150086 [2]黑龙江省农垦九三局中心医院骨科

出　　处：《药物不良反应杂志》2013年第3期168-169,共2页Adverse Drug Reactions Journal

摘　　要：1例57岁女性高血压病患者,长期口服阿司匹林、硝苯地平、富马酸比索洛尔,因冠状动脉粥样硬化性心脏病致心绞痛,加用硫酸氢氯吡格雷75 mg口服,1次/d;马来酸桂哌齐特320 mg,1次/d静脉注射。6 h后出现间歇性血尿,伴尿频、尿急、尿痛。尿常规检查示尿隐血(+++),红细胞17个/高倍视野(HP)。双肾、膀胱超声检查未见异常。停用硫酸氢氯吡格雷。次日,患者尿色逐渐恢复,尿隐血(++),红细胞4个/HP。3 d后尿常规检查正常。A 57-year-old woman, who had 20 years history of hypertension, was treated with longterm use of oral aspirin, nifedipine, and bisoprolol fumarate. Oral elopidogrel hydrogen sulfate 75 nag once daily and an IV infusion of einepazide maleate 320 mg once daily were added to her regimen due to angina pectoris caused by coronary atherosclerotie heart disease. Six hours later, the patient developed intermittent hematuria, followed by urinary frequency, urinary urgency, and urodynia. Routine urine test showed occult blood （ ＋ ＋ ＋ ） and 17 red blood eells/HP. Ultrasonography showed no abnormal changes in bilateral kidney and bladder. Clopidogrel hydrogen sulfate was withdrawn. The next day, her urine color was normalized gradually and routine urinalysis showed occult blood （ ＋ ＋ ） and 4 red blood eells/HP. Three days later, all results in the routine urine test was within normal range.

关 键 词：阿司匹林 氯吡格雷 血尿 

分 类 号：R595.3[医药卫生—内科学]