低分子肝素钙预防动静脉内瘘术后早期血栓形成的研究  

Preventive Effects of Low Molecular Weight Heparins Calcium on Early Thrombosis in the Patients with Arteriovenous Fistula

作　　者：范星[1] 彭隽[1] 任星峰[1] 兰天飙[1] 

机构地区：[1]广州军区武汉总医院肾内科,武汉430070

出　　处：《中国药师》2013年第7期1024-1026,共3页China Pharmacist

摘　　要：目的:研究低分子肝素钙对预防动静脉内瘘(AVF)钛轮钉吻合法术后早期血栓形成的影响。方法:287例行AVF钛轮钉吻合法术的患者随机分为2组,两组患者术后均常规给予双嘧达莫片50 mg,po,tid,试验组术后还立即给予低分子肝素钙4 100 IU ih,qd,连用7d。观察术后7d和术后4周两组AVF血栓形成率及不良反应发生情况。结果:276例患者完成研究(试验组137例,对照组139例)。对照组和试验组术后7 d的AVF血栓形成率分别为9.4%和2.9%,术后4周分别为11.5%和4.4%,试验组均明显低于对照组(P<0.05)对照组和试验组的ADR发生率分别为9.4%和10.2%,差异无统计学意义(P>0.05),未发生严重不良反应。结论:低分子肝素钙可明显减少动静脉内瘘钛轮钉吻合法术后早期血栓形成,安全性较好。To evaluate the efficacy of low molecular heparin in the protection of early thrombosis in the patients with arteriovenous fistula （AVF）. Method： Two hundred and eighty-seven cases were randomized to receive 50rag dipyridamole, po, tid combined with 4 100 IU low molecular heparin （the experimental group） or without low molecular heparin （the control group ） for 7 days. The patients were monitored the occurrence of complications until four weeks after the operation and early thrombosis in AVF was evaluated. Result： Eleven patients failed in follow-up and 276 patients completed the study （ 137 patients in the experimental group and 139 patients in the control group）. At 7 days and four weeks after the operation, the thrombosis rate was 2.9% and 4.4% in the experimental group and 9.4% and 11.5% in the control group, respectively. ADR incidence in the control group and the experimental group was 9.4% and 10.2% , respectively without statistical difference （ P 〉 0.05）. No serious ADR was recorded in both groups. Conclusion ： Low molecular heparin is effective and safe in the prevention of early AVF thrombosis in the chronic renal failure patients.

关 键 词：低分子肝素 慢性肾脏功能衰竭 动静脉内瘘 血栓形成 

分 类 号：R973.2[医药卫生—药品]