去乳糖奶粉辅助治疗婴幼儿轮状病毒所致腹泻病的疗效观察  

The Observation of Curative Effect of Lactose-free Formula Feeding As an Adjunctive Therapy on Diarrhea Induced by Rotavirus in Infants

作　　者：周晶[1] 王评[1] 

机构地区：[1]吉林省吉林市儿童医院,吉林吉林132001

出　　处：《中国医药指南》2013年第19期452-453,共2页Guide of China Medicine

摘　　要：目的探讨去乳糖配方奶粉对婴幼儿轮状病毒所致腹泻病辅助治疗作用。方法采用严格的双盲、随机、对照等效性试验,将119例以乳类喂养为主的轮状病毒所致腹泻病患儿随机分为两组,两组均给予常规药物和补液等治疗。观察组停止乳类喂养,改用去乳糖奶粉,对照组继续乳类喂养,对两组疗效及病程进行比较。结果去乳糖组腹泻的治愈率及总有效率分别为43.08%和90.77%;常规组治愈率及总有效率分别为12.96%和51.85%,两组疗效的差异有显著性意义(P<0.05)。去乳糖组腹泻缓解天数为(3.23±1.41)d,明显低于常规组的(4.51±1.02)d(P<0.05)。两组均无明显的不良事件发生。结论去乳糖奶粉联合腹泻常规治疗方案治疗婴幼儿轮状病毒所致腹泻病能明显减轻症状,缩短病程,提高治疗效果。Objective To study the efficiency of lactose-free formula feeding as an adjunctive therapy in infants with diarrhea induced by rotavirus infection. Methods A rigorous double-blind, randomized, controlled equivalence trial was performed. One hundred and nineteen infants who were mainly fed by conventional formula with diarrhea induced by rotavirus infection were randomly divided into two groups： the infants in one group were fed with lactose- free formula instead of conventional formula, the infants in the other group as control were fed with conventional formula continuously. Both groups were given conventional medical treatment and oral rehydration therapy simultaneously. The symptom course and therapeutic effects were contrasted during the treatments. Results The cure rate and the total effective rate in the lactose-free formula group were 43.08% and 90.77% respectively, and they were 12.96% and 51.85% respectively in the conventional formula group. There were significant differences in the therapeutic effect between the two groups （P〈0.05）. The duration of diarrhea remission （3.23＋l.41）days in the lactose-free formula group was significantly shorter than that in the conventional formula group （4.5 l~：l.02）days （P〈0.05）. After treatment the incidence of fecal flora disturbance was lower in the lactose-free formula group than that in the conventional formula group （p〈0.05）. No adverse events were observed in the two groups. Conclusions Lactose-free formula feeding together with conventional therapy can significantly alleviate symptom, shorten the disease course, and improve the treatment effect in infants with diarrhea induced by rotavirus infection.

关 键 词：轮状病毒 腹泻病 去乳糖奶粉 疗效 

分 类 号：R725[医药卫生—儿科]