四氯对苯醌为受体荷移分光光度法测定苯唑西林钠  

Spectrophotometric determination of oxacillin sodium by charge-transfer reaction with p-chloranil

作　　者：刘芝平[1] 宋健玲[1] 

机构地区：[1]太原理工大学化学化工学院,太原030024

出　　处：《分析仪器》2013年第4期12-15,共4页Analytical Instrumentation

基　　金：国家自然科学基金(No.30472125)

摘　　要：研究了在乙醇溶液中苯唑西林钠与四氯对苯醌发生荷移反应,生成稳定的1∶1络合物,线性范围为40～400μg/mL,最大吸收波长为424.8nm,表观摩尔吸光系数为ε=4.32×102 L.mol-1.cm-1,回收率为98.74%-100.3%,相对标准偏差≤2.56%。该方法简便、快速可用于测定药物制剂中苯唑西林钠的含量,结果满意。A new spectrophotometric method has been developed for the determination of oxacillin sodium. It is based on a reaction of charge transfer with p-chloranil in ethanol medium. The composition of complex of oxacillin sodium with p-chloranil both was 1 ： 1. The calibration curves are linear in the concentration range of 40-400 μg/mL. The complexe maximum absorption was at 424.8 nm. The apparent molar absorptivity of complex was ε=4.32× 102 L. mol^-1. cm^-1. The recovery is 98.74%-100.3% and the relative standard deviation is≤2.56 %. The proposed method has been applied to the determination of oxacillin sodium for injection and capsules form with satisfactory results.

关 键 词：分光光度法 四氯对苯醌 荷移反应 苯唑西林钠 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.3[化学工程—制药化工]