急性心肌梗死后早期微量蛋白尿的自然变化规律及临床相关性研究  

Observations and clinical analysis of variation of microalbuminuria after acute myocardial infarction

作　　者：阮蕾[1] 闫亚非[1] 罗彩东[2] 王羽[2] 郑铿[1] 秦方[1] 吴屹[1] 王静[1] 汤雁蓉[1] 张静[1] 陈航[1] 付莉[1] 刘童[1] 

机构地区：[1]四川省成都市第一人民医院心内科,成都610041 [2]四川省绵阳市中心医院心内科,四川绵阳621000

出　　处：《岭南心血管病杂志》2013年第4期398-401,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的观察急性心肌梗死(acute myocardial infarction,AMI)患者早期微量蛋白尿(microalbuminuria,MA)的自然变化规律,并对其进行临床相关性研究。方法对连续入选的602例胸痛患者进行研究。所有患者于住院当日、第3天和第7天检查尿微量蛋白肌酐比值,大于或等于300μg/mg定义为MA阳性。同时检查N末端脑钠肽前体(N-terminal B-type brain natriuretic peptide,NT-proBNP)。结果 AMI后MA呈动态变化,心肌梗死后当天即开始升高,第3天达峰,第7天时下降。三个时间点MA阳性率分别为35.9%、50.8%和15.8%。MA的水平和心肌梗死的面积明显相关(r=0.56,P<0.05)。结论 AMI后MA反应性升高,且呈动态变化,其变化与梗死面积和心功能相关。Objectives To observe the dynamic changes of microalbuminuria （MA） after acute myocardial infarction （AMI） in patients. Methods Totally 602 patients with pectoralgia were included in the study. Urinary albumin excretion, expressed as microalbumin/creatinine ratio, was measured at day 1, 3 and 7. The value of this ratio not less than 300 μg/mg was defined as MA positive. Also N-terminal pro-B-type brain natriuretic peptide （NT-proBNP） was tested. Results MA significantly elevated at day 1, climaxed at day 3, and declined at day 7 after AMI. The positive rates of MA at these time points were 35.9%, 50.8% and 15.8%. There was a strong relation between MA and infarction areas （r=0.56, P〈O.05）. Conclusions There is a dynamic change in microalbuminuria in patients after AMI, which is related to infarction areas and cardiac function.

关 键 词：急性心肌梗死 微量蛋白尿 脑钠肽 

分 类 号：R542.22[医药卫生—心血管疾病]