扩张型心肌病患者E23K多态性与心功能的关系  

Relationship between E23K polymorphism and cardiacfunction in dilated cardiomyopathy

作　　者：罗臻[1] 万军[1] 刘剑芳[1] 席红玲[1] 赵生娣[1] 王梦龙[1] 刘梦林[1] 

机构地区：[1]武汉大学人民医院心内科,武汉430060

出　　处：《临床心血管病杂志》2013年第7期521-523,共3页Journal of Clinical Cardiology

基　　金：国家自然基金资助项目(No:302163548);湖北省自然基金资助项目(No:302131725)

摘　　要：目的:研究扩张型心肌病(DCM)患者KATP通道亚单位Kir6.2上E23K多态性与心功能的关系。方法:选取DCM患者89例,采用心脏多普勒超声二维成像技术,检测左室舒张末期内径(LVEDD)和左房内径(LAD),并运用PCR等分子生物学技术,对KATP通道上的亚单位Kir6.2进行扩增测序。结果:89例DCM患者中,E23K突变55例,E23K无突变34例。在E23K突变组和E23K无突变组中LVEDD分别为(65.52±1.27)mm和(61.31±1.02)mm(P=0.017);LAD分别为(46.24±1.39)mm和(42.54±1.18)mm(P=0.044)。结论:E23K突变组LVEDD和LAD较无突变组显著扩大。Objective：To evaluate the relationship between E23K polymorphism in KATP channel and cardiac function. Method：All 89 patients with DCM were checked by Doppler echocardiography on left ventricular end diameter diastolic （LVEDD） and left atrial diameter （LAD）. Using PCR, we sequenced the Kir6.2 gene （1.3 kb） in 8 9 DCM palients which were classified into mutation group and non mutation group . Result ： The LVEDD in DCM patients carrying E23K wlriant was significantly elevated compared with that in DCM patients without E23K wlriant [-（65.52±1.27）mm vs （61.31±1.02）mm, P=0.0171. Similarly, the LAD was also increased in paliems with E23K variants [（,16.24±1.39）mm vs （42.54±1.18）mm, P=0.041]. Conclusion：E23K polymorphism is associated with LVEDD and LAD in DCM patients. Key words

关 键 词：扩张型心肌病 KATP E23K多态性 左室舒张末期内径 左房内径 

分 类 号：R542.2[医药卫生—心血管疾病]