胱抑素C水平与慢性心力衰竭患者心功能及预后关系的研究  

Relationship of cardiac function and prognosis with cystatin C level inpatients with chronic heart failure

作　　者：季群[1] 李正章[1] 沈哲[1] 薛豪平 程石[1] 薛敏芝[1] 

机构地区：[1]江苏省高邮市人民医院心内科,江苏高邮225600

出　　处：《临床心血管病杂志》2013年第7期527-529,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨慢性充血性心力衰竭(CHF)患者胱抑素C水平的变化及其与心功能关系和对CHF患者预后的影响。方法:入选CHF患者192例,按照胱抑素C水平分为正常组(112例)及增高组(80例)。采用胶乳比浊法检测胱抑素C水平和超声心动图测量患者心功能参数,并对两组患者在随访期间心血管事件进行分析。结果:随访期间胱抑素C增高组与正常组再住院率为31.25%与10.57%、病死率为15.00%与3.57%,均差异有统计学意义(均P<0.01)。CHF患者的胱抑素C水平与左室射血分数呈负相关。结论:CHF患者常伴有不同程度胱抑素C水平升高,与CHF严重程度有关。胱抑素C水平可预测CHF患者的预后。Objective： To investigate the relationship between the cardiac function and cystatin C level in patients with chronic congestive heart failure （CHF）. Method：The 192 CHF patients were divided into the normal group and the increased group according to the level of cystatin C. I.atex turbidimetric measured cystatin C level and heart function parameters were detected by ultrasonic cardiogram. Result： The follow-up period of re-hospitali- zation rates in cystatin C increased group and normal group were 31.25% and 10.57% （P〈0.01）. The mortality rates in cystatinCincreased group and normal group were 15.00% and 3.57% （P〈0.01）. A negative correlation between cystatin C level and LVEF in patients with CHF. Conclusion： CHF patients is often accompanied by var- ying degrees of cystatin C level, which is related to the severity of CHF. Cystatin C level can predict the prognosis of patients with CHF.

关 键 词：慢性心力衰竭 胱抑素C 心功能 预后 

分 类 号：R541.6[医药卫生—心血管疾病]