冠心病患者甲状腺素水平的研究  

Thyroid hormone in patient with coronary heart disease

作　　者：胡文兰[1] 赵兴山[1] 韩昊[1] 马旃[1] 徐新娜[1] 赵颖[1] 

机构地区：[1]北京积水潭医院心内科,北京100035

出　　处：《临床心血管病杂志》2013年第7期545-546,共2页Journal of Clinical Cardiology

摘　　要：甲状腺激素（TH）是维持机体生长、发育和糖脂代谢的主要激素之一。TH在循环和组织中的正常水平对维持心血管系统的正常功能至关重要。具有生物活性的三碘甲状腺原氨酸（T3），可调节多种结构蛋白及功能蛋白基因表达，改变心肌细胞形态，增加其收缩力，降低外周血管阻力，从而影响血流动力学。近年来，人们逐渐关注TH在心血管疾病中的作用。本研究旨在探讨不同冠心病患者TH水平的变化。Summary We sought to describe thyroid hormone （TH） profile in patients with coronary heart diseasc. The 122 consecutive patients hospitalized for elective diagnostic coronary angiography were studied, including 28 con- trol subjects, 28 patients with unstable angina （UA）, 30 patients with stable angina （SA） and ？,6 patients with acute myocardiac ini＇rarction （AMI）. Serum levels of high-sensitivity CRP （hs CRP） and TH were detected. The results showed that serum TS and FT3 significantly decreased in UA and AMI group in comparison with SA and control groups. In addition, we found independent negative correlations between T3, FT3 and hs-CRP.

关 键 词：冠心病 甲状腺素 不稳定型心绞痛 急性心肌梗死 炎症 

分 类 号：R541.4[医药卫生—心血管疾病]