西拉普利对急性心肌梗死大鼠TNF-α及BNP的影响  

Effect of Cilazapril on TNF-α and BNP in rats with acute myocardial infarction

作　　者：赵茹[1] 张茹艳[2] 宋衍秋[3] 胡越成[1] 丛洪良[1] 

机构地区：[1]天津市胸科医院心内科,天津300051 [2]天津医科大学临床学院 [3]天津市心血管病研究所

出　　处：《临床心血管病杂志》2013年第7期549-550,共2页Journal of Clinical Cardiology

摘　　要：急性心肌梗死（AMI）后心脏利钠肽系统即被激活，导致心室B型钠尿肽（BNP）水平升高，一方面，可对抗肾素-血管紧张素-醛固酮系统（RAAS）的缩血管作用，另一方面，压力及容量负荷促进心肌组织分泌心房钠尿肽和BNP的同时，Summary We observed the changes of TNF-α and BNP in rats after acute myocardial infarction （AMI）, and examined the effect of Cilazapril on them. Seventy Wistar male rats were randomly divided into sham-operated group and operated group, the latter was further divided into AMI group and Cilazapril group. There were signifi- cant differences between AM1 group and sham-operated group concerning the levels of TNF-α and BNP in plasma. TNFα and BNP in Cilazapril group were significantly lower comparing with AMI group. Cilazapril can reduce TNF-α and BNP in blood and myocardial.

关 键 词：心肌梗死 急性 西拉普利 B型利钠肽 肿瘤坏死因子-Α 

分 类 号：R542.2[医药卫生—心血管疾病]