白癜风患者血清甲状腺自身抗体水平研究  

Research on serum thyroid autoantibodies levels in patients with vitiligo

作　　者：贾名妍[1] 苗青[1] 于伟[1] 张艺杰[1] 

机构地区：[1]郑州大学第一附属医院皮肤科,河南郑州450052

出　　处：《中国美容医学》2013年第14期1503-1506,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:检测白癜风患者血清甲状腺自身抗体水平,探讨白癜风与自身免疫性甲状腺疾病的相关性。方法:收集白癜风患者40例,年龄和性别相匹配的38例健康人为对照组。采用化学发光免疫分析法测定白癜风患者和对照组血清抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)的水平。结果:白癜风患者血清TPOAb和TGAb的阳性率明显高于对照组。白癜风患者TPOAb阳性率为25.00%,高于对照组的2.63%(P<0.05)。白癜风患者TGAb阳性率为22.50%,高于对照组的5.26%(P<0.05)。女性白癜风患者TPOAb和TGAb阳性率高于男性(P<0.05)。21～30岁年龄段白癜风患者TPOAb和TGAb阳性率高于其他年龄段白癜风患者(P<0.05)。白癜风患者TPOAb和TGAb的阳性率在不同的临床分型、临床分期无统计学差异。结论:青年女性白癜风患者TPOAb和TGAb阳性率高,白癜风与自身免疫性甲状腺疾病存在相关性。临床医生应该意识到白癜风伴发自身免疫性甲状腺疾病的风险,做到早期筛查,早发现、早治疗。Objective To measure the level of the serum thyroid autoantibodies in patients with vitiligo and investigate the relationship between vitiligo and autoimmune thyroid diseases. Methods 40 patients with vitiligo were enrolled and 38 age and sex-matched healthy individuals served as controls.The levels of TPOAb and TGAb of patients with vitiligo and controls were measured by chemiluminescent immunoassay. Results The positivity of TPOAb and TGAb in the serum of patients with vitiligo was higher than that in controls significantly. The positivity of TPOAb in patients with vitiligo was 25.00%, higher than that in controls （2.63% for TPOAb,P〈0.05）.The positivity of TGAb in patients with vitiligo was 22.50%, higher than that in controls（5.26% for TGAb,P〈0.05）. The positivity of TPOAb and TGAb in female patients with vitiligo was higher than that in male patients （P〈0.05）.The positivity of TPOAb and TGAb in patients with vitiligo in 21-30 years old was higher than that in patients with vitiligo in the other age （P〈0.05）. In the different clinical classification and clinical stage, there were no statistical differences in the positivity of TPOAb and TGAb in patients with vitiligo （P〉0.05）. Conclu- sions The positivity of TPOAb and TGAb in young female patients with vitiligo was high,and there were correlation between vitiligo and autoimmune thyroid diseases.Clinicians should be aware of the risk of the concurrence of vitiligo and autoimmune thyroid disease, and ensure early screening, early detection and early treatment.

关 键 词：白癜风 甲状腺自身抗体 自身免疫性甲状腺疾病 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]