卤代呋喃酮/聚乳酸缓释微球的制备及其体外释药特性研究  

Preparation and in vitro release behavior of halogenated furanone polylactic acid microspheres

作　　者：姚军燕[1] 程义成[2] 赵雯[2] 郑振超[1] 高勃[2] 吴江[2] 

机构地区：[1]西北工业大学理学院应用化学系,西安710072 [2]第四军医大学口腔医学院修复科

出　　处：《实用口腔医学杂志》2013年第4期482-486,共5页Journal of Practical Stomatology

基　　金：国家自然科学基金资助(编号:51001116)

摘　　要：目的:以聚乳酸为载体材料制备卤代呋喃酮缓释微球,并研究其体外释药特性。方法:采用乳化-溶剂挥发法制备卤代呋喃酮/聚乳酸缓释微球,通过正交试验筛选最优制备工艺参数;考察微球的形态,粒径以及载药量、包封率等特征,并通过透析法进行微球体外释药研究。结果:卤代呋喃酮聚乳酸微球的最佳制备工艺稳定、重复性好,微球表面圆整,粒径分布均匀,平均粒径为(416±23)nm,载药量为(10.45±0.46)%,包封率为(60.82±1.01)%。该微球在60 d的药物累积释放率达90.2%。结论:卤代呋喃酮聚乳酸微球缓释时间长达60 d,在牙种植体抗菌方面具有良好的应用前景。Objective：To prepare microspheres containing halogenated furanone with polylactic acid and to investigate the release behavior of halogenated furanone microspheres in vitro.Methods： Halogenated furanone polylactic acid microspheres were prepared by emulsion solution-evaporation,and the orthogonal test design was used to optimize the technology of preparation.The morphology,particle size,drug loading,incorporation efficiency and release behavior of the microspheres were examined.Results： The halogenated furanone polylactic acid microspheres showed good spherical geometry and suitable size distribution under scanning electron microscope.The average diameter of microspheres were（416±23） nm;the drug loading and incorporation efficiency were（10.45±0.46）% and（60.82±1.01）%,respectively.The cumulative release rate was 90.2% in 60 days.Conclusion： The halogenated furanone microspheres have sustained release of halogenated furanone over a 60 day period.

关 键 词：卤代呋喃酮 聚L乳酸 载药微球 体外释放 

分 类 号：R944.9[医药卫生—药剂学]