原花青素对高脂血症大鼠血脂、脂蛋白磷脂酶A2的影响及意义  

Effects of Proanthocyanidins on Serum Levels of Cholesterol,Triglycerides,High Density Lipoprotein,and Lipoprotein-Associated Phospholipase A2 of Rats with Hyperlipidemia

作　　者：邹金发[1] 叶丽平[1] 姚素艳[1] 刘晓光[1] 

机构地区：[1]辽宁医学院病理生理学教研室,辽宁锦州121000

出　　处：《武汉大学学报（医学版）》2013年第4期516-519,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨原花青素(OPC)对高脂血症大鼠血脂的影响及意义。方法:选择96只高脂血症大鼠,随机分成模型组16只、原花青素组80只,原花青素组再随机分为原花青素2,4,6,8,10mg/kg组,每组各16只。另取16只非高脂血症大鼠大鼠作为对照组。原花青素2,4,6,8,10mg/kg组每天给予相应剂量的原花青素灌胃1次,模型组、对照组每天给予与原花青素组相同体积的生理盐水1次,共灌胃2周。分别检测灌胃前后各组血清总胆固醇(TC)、甘油二酯(TG)、高密度脂蛋白(HDL)和脂蛋白磷脂酶A2(Lp-PLA2)水平。结果:随着原花青素浓度增加,血清TC、TG、Lp-PLA2水平显著降低(P<0.05),血清HDL水平显著升高(P<0.05)。8mg/kg和10mg/kg剂量组中TC和TG恢复正常比例显著高于2,4,6mg/kg组(P>0.05),6,8,10mg/kg剂量组中大鼠HDL和Lp-PLA2恢复正常比例显著高于2mg/kg和4mg/kg组(P<0.05)。结论:原花青素具有降低血脂作用,且其效果具有剂量依赖性。Objective： To study the effects of proanthocyanidins on serum cholesterol, triglycerides, HDL, and lipoprotein-associated phospholipase（Lp-PLA2） of rats with hyperlipidemia, and to investigate the medicinal value of proanthocyanidins. Methods： Ninety-six rats with hyperlipi- demia were divided into model group （n=16）, 2 mg/kg group （n=16）, 4 mg/kg group （n=16）, 6 mg/kg group （n=16）, 8 mg/kg group （n=16） and 10 mg/kg group, and another 16 rats with- out atherosclerosis were set as control group. Concentrations of serum total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, and Lp-PLA2 were calculated. Results： With the increasing dose of proanthocyanidins, serum TC, TG, and Lp-PLA2 concentrations re- duced significantly （all P〈0.05）, and serum HDL levels increased significantly （P〈0.05）. The case numbers of normal cholesterol and triglycerides in 8 mg/kg and 10 mg/kg groups were sig- nificantly more than those respectively in 2, 4, and 6 mg/kg groups （P〈0. 05）, and normal HDL and Lp-PLA2 cases in 6, 8, and 10 mg/kg groups were significantly more than those of 2 mg/kg and 4 mg/kg groups （P〈0. 05）. Conclusion. Proanthocyanidin has potential medicinal value for inhibiting blood lipids, and the effect is dose dependent.

关 键 词：原花青素 大鼠 血脂 脂蛋白磷脂酶A2 

分 类 号：R589.2[医药卫生—内分泌]