HDAC1-11 mRNA在出生后大鼠坐骨神经发育过程中的表达变化  

HDAC1-11 mRNA expression during postnatal development of rat sciatic nerve

作　　者：王亚洲[1] 鞠少卿[1] 王小飞[1] 

机构地区：[1]南通大学附属医院医学检验中心,南通226001

出　　处：《神经解剖学杂志》2013年第4期455-458,共4页Chinese Journal of Neuroanatomy

摘　　要：目的:研究组蛋白去乙酰化酶HDAC1-11 mRNA在大鼠出生后坐骨神经发育过程的变化。方法:RT-PCR法分析坐骨神经发育成熟过程是HDAC1-11mRNA的表达水平。结果:HDAC1-11 mRNA持续表达于大鼠坐骨神经发育成熟的过程中,在大鼠60 d时表达水平显著的低于初生时的表达水平。结论:HDAC1-11 mRNA参与大鼠坐骨神经发育成熟的过程,且其表达水平随着大鼠年龄的增加呈现由高到低的动态变化,提示其与坐骨神经髓鞘的发育成熟以及维持神经的正常功能密切相关。Objective： To observe HDAC1-11 mRNA expression during postnatal development of rat sciatic nerve. Methods： RT-PCR method was used to investigate the expression of HDAC1-11 mRNA in sciatic nerve of rat during post- natal development. Results： HDAC1-11 mRNA continued expression in the rat sciatic nerve maturation process, the ex- pression level of 60 days rat was significantly lower than that of newborn rats. Conclusion： HDAC1-11 mRNA partici- pates in the rat sciatic maturation process, and its expression levels show high to low dynamic change. It is suggested that HDAC1-11 mRNA is closely related to sciatic nerve myelin maturation and maintain normal nerve function.

关 键 词：HDAC1-11mRNA 坐骨神经 发育 大鼠 

分 类 号：R338[医药卫生—人体生理学]