血清salusin-α水平与高血压病患者并发冠心病的相关性分析  

Association between serum salusin-α level and the presence of coronary artery disease in hypertensive patients

作　　者：陈平[1] 游学文[1] 陈启光[1] 陈建文[1] 孙伏清[1] 

机构地区：[1]福清市医院心血管内科,福建福清350300

出　　处：《中华实用诊断与治疗杂志》2013年第8期765-766,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：2011年福清市科研项目(20111225)

摘　　要：目的探讨血清salusin-α水平在高血压病并冠心病患者中的变化及意义。方法 174例高血压病患者根据是否并发冠心病分为并发冠心病组86例和非冠心病组88例,应用ELISA法检测2组血清salusin-α水平。多元logistic回归分析评价各变量与并发冠心病的相关性。结果冠心病组患者血清salusin-α水平((1.53±0.47)ng/mL)明显低于非冠心病组((2.17±0.69)ng/mL)(P<0.01);多元logistic回归分析结果显示,血清salusin-α水平与高血压并发冠心病呈独立负相关(OR=0.815,95%CI∶0.764～0.939,P<0.01)。结论低血清salusin-α水平是高血压并发冠心病的独立危险因子。Objective To investigate the relationship between serum salusin-α level and the presence of coronary artery disease （CAD） in hypertensive patients. Methods A total of 174 patients with hypertension were divided into CAD group （n=86） and non-CAD group （n=88）. Serum salusin-α level was measured in two groups with ELISA. The association between the variables and the presence of CAD was investigated by multivariant logistic regression analysis. Results Serum salusin-α level was significantly lower in CAD group than that in non-CAD group （（1.53±0.47） vs （2.17±0.69） ng/rnL） （P〈0.01）. Multivariate logistic regression analysis demonstrated that serum salusin-α level was independently and negatively correlated with the presence of CAD in hypertension patients （OR = 0. 815, 95 % CI： 0. 764 to 0. 939） （P〈 0.01）. Conclusion The serum salusin-α level is an independent risk factor for the presence of CAD in hypertensive patients.

关 键 词：冠心病 高血压 salusin-α 生物标记物 

分 类 号：R541.4[医药卫生—心血管疾病]