连朴饮合半夏泻心汤加减治疗脾胃湿热证慢性浅表性胃炎55例  

Efficacy of Lianpu Drink Combined with Pinellia Ternate Soup for Removing the Stomach-Fire on Damp Heat Syndrome of Chronic Superficial Gastritis:Clinical Observation of 55 Cases

作　　者：李兴华[1] 江玉[2] 郝小鹰[1] 

机构地区：[1]自贡市中医院,四川自贡643000 [2]泸州医学院附属中医院,四川泸州646000

出　　处：《中国实验方剂学杂志》2013年第15期293-297,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省教育厅项目(11ZB130)

摘　　要：目的:观察连朴饮合半夏泻心汤加减治疗脾胃湿热证慢性浅表性胃炎(CSG)的临床疗效及对血清超氧化物歧化酶(SOD)影响。方法:110例CSG(脾胃湿热证)患者随机按数字法分为对照组和观察组各55例。对照组口服施维舒胶囊,1粒/次,3次/d。观察组采用连朴饮合半夏泻心汤加减,1剂/d,常规水煎分2次服用,两组疗程均为8周。进行治疗前后胃镜检查,观察脾胃湿热证积分及幽门螺旋杆菌(HP)清除率,并检测治疗前后血清SOD水平。结果:对照组内镜下胃黏膜疗效总有效率为81.8%,观察组为96.4%,观察组优于对照组(P<0.05);对照组胃黏膜组织学疗效总有效率为78.2%,观察组为96.4%,观察组优于组(P<0.01);治疗后观察组脾胃湿热证积分均明显降低,并低于对照组(P<0.01);对照组中医证候疗效总有效率76.4%,观察组为98.2%,观察组优于对照组(P<0.01);治疗后观察组餐后饱胀不适、早饱感和上腹部疼痛的总有效率分别为91.1%、90.9%和90.4%均优于对照组的67.4%、64.3%和75.0%(P<0.01);对照组HP清除率65.9%,观察组清除率80%,差异无统计学意义;治疗后观察组血清SOD水平明显上升,并高于对照组(P<0.01);对照组复发率66.7%,观察组复发率39.4%,观察组低于对照组(P<0.05)。结论:连朴饮合半夏泻心汤加减能明显减轻CSG(脾胃湿热证)的临床症状,临床疗效好,并能杀灭HP,提高血清SOD,降低复发率,值得临床使用。Objective： To observe the clinical efficacy of Lianpu drink combined with Pinellia ternate soup for removing the stomach-fire on damp heat syndrome of Chronic Superficial Gastritis（CSG） and its effect on serum superoxide dismutase（SOD）.Method： One hundred and ten patients with CSG（chronic superficial gastritis） were divided into control group and observation group,55 patients in each.The control group took Selbex capsules orally 3 times per day and 1 grain per time,while the observation group received Lianpu drink combined with Pinellia ternate soup for removing the stomach-fire 1 dose per day.The treatment courses were both 8 weeks.Stomachoscopy was given before and after the treatment,the score of the damp heat syndrome was assessed,the clearance rate of the Helicobacter Pylori（HP） was calculated,and the SOD levels in serum were detected.Result： the total effective rate of the gastric mucosa of the control group under the endoscope was 81.8%,which was significantly lower than that of the observation group（96.4%,P 0.05）.As for the total effective rate of the gastric mucosa histology,observation group was markedly higher than the control group,（96.4% vs 78.2%,P 0.01）.The total effective rate of the TCM syndrome of the control group was 76.4%,while that of the observation group was 98.2%,which is better than the control group（P 0.01）.the total effective rate of abdominal fullness,early fullness,and aching in the upper stomach after dinner of the observation group were 87.3%,90.9% and 92.7% respectively,all better than those of the control group,which were 65.5%,67.3% and 69.1%（P 0.01）.The HP clearance rate of the control group was 65.9%,while that of the observation group was 80%,and the difference was of no statistical significance.The SOD level in serum of the observation group after treatment increased significantly,and was higher than that of the control group（66.7% vs 39.4%,P 0.01）.Conclusion： Lianpu drink combined with Pinellia ternate soup for removing the stomach

关 键 词：慢性浅表性胃炎 脾胃湿热证 连朴饮 半夏泻心汤 临床疗效 

分 类 号：R287[医药卫生—中药学]