基于文本挖掘探索溃疡性结肠炎药物的治疗规律  

Exploration of Drug Treatment Law for Ulcerative Colitis Based on Text Mining Technology

作　　者：刘元艳[1] 刘学文[2] 谭勇[3] 赵思宇[1] 郭洪涛[3] 郑光[3] 姜淼[3] 吕爱平[3] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]首都医科大学潞河教学医院中医科,北京101100 [3]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中国实验方剂学杂志》2013年第15期329-332,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部"重大新药创制"项目(2009ZX09502-019);科技部创新方法学专项(2008IM020900);国家自然科学基金青年科学基金项目(30902000;81001623);北京中医药大学课题(2009JYBZZ-JS037)

摘　　要：目的:探索溃疡性结肠炎的中西药用药规律。方法:利用数据挖掘技术,结合可视化,在中国生物医学文献数据库中收集治疗溃疡性结肠炎的文献数据,采用基于敏感关键词频数统计的数据分层算法,结合文献回溯、人工阅读降噪,挖掘溃疡性结肠炎的中西药治疗规律。规律通过一维频次及二维的网络图进行显示。结果:治疗溃疡性结肠炎使用频数排在前五的西药依次为柳氮磺吡啶、甲硝唑、地塞米松、泼尼松和氢化可的松,地塞米松最常与其他西药联用。治疗溃疡性结肠炎使用频数排在前五的中成药依次为云南白药、乌梅丸、补脾益肠丸、理中丸和西瓜霜,中草药依次为黄连、白术、白头翁、黄芪和乌梅。补中益气丸和补脾益肠丸常与其他中成药联用,黄芪、黄连、白术常与其他中草药联用,补脾益肠丸、云南白药和乌梅丸常与地塞米松、甲硝唑、柳氮磺吡啶联用。结论:文本挖掘技术能较客观地总结溃疡性结肠炎中西药的用药规律,为临床经验总结提供有益的探索与参考。Objective： To explore treatment law of ulcerative colitis with traditional Chinese medicine and western medicine.Method： Taking data mining technology,combined with visualization,literarure data for treating ulcerative colitis were collected in Chinese biomedical literature database.Data slicing algorithm based on sensitive keywords frequency statistics was adopted,combined with literature review and artificial reading noise reduction,then treatment law of traditional Chinese medicine and western medicine for ulcerative colitis was investigated.Law showed of one-dimensional and two-dimensional network diagram.Result： Using frequency of western drugs for treatment of ulcerative colitis was in order of sulfasalazine metronidazole dexamethasone prednisone hydrocortisone,dexamethasone was commonly associated with other western medicine;Using frequency of Chinese patent drugs was in order of Yunnan Baiyao Wumei pills Bupi Yichang pills Lizhong pills mirabilitum praeparatum,Buzhong Yiqi pills and Bupi Yichang pills was always associated with other Chinese patent drugs;Chinese materia medica was in order of Rhizoma Coptidis Rhizoma Atractylodis Macrocephalea Radix Pulsatillae Radix Astragali Fructus Mume,Rhizoma Coptidis,Rhizoma Atractylodis Macrocephalea and Radix Astragali often combined with other herbs;Bupi Yichang pills,Yunnan Baiyao and Wumei pills were always associated with dexamethasone,metronidazole and sulfasalazine.Conclusion： Text mining technology could be adopted for objective summing up treatment law of traditional Chinese medicine and western medicine for ulcerative colitis,then provide useful exploration and reference to clinical experience.

关 键 词：文本挖掘 溃疡性结肠炎 药物治疗规律 中西药 配伍规律 

分 类 号：R283.6[医药卫生—中药学]