血清C-反应蛋白和胱抑素C联合检测对痛风患者早期肾功能损伤的诊断价值  

Diagnostic value of combined detection of CRP and Cys C for early renal function impairment in gout patients

作　　者：周阳春[1] 李云霞[2] 唐彦[3] 

机构地区：[1]四川省自贡市第一人民医院检验科,643000 [2]重庆医科大学附属第二医院病案统计科,400010 [3]重庆市中医骨科医院检验科,400012

出　　处：《重庆医学》2013年第22期2619-2620,2623,共3页Chongqing medicine

摘　　要：目的探讨C-反应蛋白(CRP)和胱抑素C(Cys C)联合检测对痛风患者早期肾功能损伤的诊断价值,为临床提供参考依据。方法选择四川省自贡市第一人民医院及重庆中医骨科医院住院和门诊痛风患者200例,根据肾小球滤过率(GFR)分为痛风伴肾功能早期损伤组(GFR 60～<90mL/min)和痛风不伴肾功能损伤组(GFR≥90mL/min),每组各100例。用透射免疫比浊法在OLYMPUS AU 400全自动生化分析仪上检测患者血清中CRP和Cys C水平。结果痛风伴肾功能早期损伤组患者血清CRP和Cys C水平均显著高于痛风不伴肾功能早期损伤组,二者比较差异有统计学意义(P<0.05)。痛风伴肾功能早期损伤组患者血清CRP和Cys C阳性率分别为75%和81%,二者比较差异无统计学意义(P>0.05)。而CRP和Cys C联合检测的阳性率为92%,显著高于单一指标的阳性检出率(P<0.05)。结论 CRP和Cys C联合检测可明显提高痛风患者早期肾功能损伤的阳性检出率。Objective To evaluate the diagnostic value of combined detection of c-reactive protein（CRP）and cystatin C（Cys C） for early renal function impairment in gout patients,and to provide clinical reference.Methods Two hundred cases of gout patients were investigated and divided into experimental group and control group：experimental group patients（n=100）were with early renal function impairment and the control group（n=100）were without early renal impairment.The concentration of CRP and Cys C were detected with turbidimetric immunoassay method by OLYMPUS AU 400 automatic biochemistry analyzer.Results Serum CRP and Cys C concentrations of gout patients with early renal function impairment were significantly higher than those of gout patients without early renal function impairment（P0.05）.In the group of gout patients with early renal function impairment,the positive rate of serum CRP（75%）and Cys C（81%）had no significant difference（P0.05）.The positive rate of combination detection of CRP and Cys C was 92%,which was significantly higher than either CRP or Cys C（P0.05）.Conclusion The combination detection of CRP and Cys C can improve diagnostis of early renal function impairment in gout patients.

关 键 词：C-反应蛋白 胱抑素C 痛风 

分 类 号：R692[医药卫生—泌尿科学]