松针提取物对Ⅱ型糖尿病大鼠的抗氧化作用  

Antioxidative Effects of Pine Needle Extract on Rats with Type 2 Diabetes

作　　者：王春梅[1] 杜兴旭[2] 

机构地区：[1]北华大学药学院,吉林吉林132013 [2]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2013年第4期426-428,共3页Journal of Beihua University（Natural Science）

基　　金：吉林市科委项目(2011328a)

摘　　要：目的观察松针提取物(Pine needle extract,PNE)对高脂饮食联合链脲佐菌素(STZ)诱导的Ⅱ型糖尿病大鼠治疗作用及其抗氧化作用.方法采用高脂饮食联合小剂量STZ(30 mg/kg)腹腔注射诱导Ⅱ型糖尿病大鼠模型,用PNE(200,400,800 mg/kg)治疗4周,测定空腹血糖、血清甘油三酯(TG)、总胆固醇(TC)含量,测定血清氧化亚氮(NO)、丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性.结果 PNE可显著降低Ⅱ型糖尿病大鼠的空腹血糖、TG及TC水平,明显降低血清NO,MDA水平,同时可提高血清SOD活性.结论 PNE可显著降低Ⅱ型糖尿病大鼠血糖和血脂水平,对糖尿病大鼠具有一定的治疗作用,其机制可能与松针抗氧化作用有关.Objective To investigate the on rats with type 2 diabetes induced by therapeutic effect＇and antioxidative high fat diet and STZ. Method effect of pine needle extract （PNE） Type 2 diabetic animal model was established by high-fat diet and low dose of STZ. After treatment with PNE （200,400,800 mg/kg）for 4 weeks, the serum fasting blood glucose （ FBG ）, total cholesterol （ TC ）, triglyceride （ TG ） levels, nitric oxide （ NO ） activities, superoxide dismutase （SOD）activities and malondialdehyd （MDA）levels were measured. Results Compared with those in diabetic group, FBG,TC and TG levels in diabetic rats treated with PNE were significantly decreased. PNE treatment significantly reduced NO activities and MDA levels, and elevated SOD activities in diabetic rats. Conclusion PNE can decrease blood glucose and blood lipids, has a therapeutic effect on rats with type 2 diabetes. The mechanism may be related to the antioxidant effect.

关 键 词：松针提取物 Ⅱ型糖尿病 抗氧化作用 

分 类 号：R285[医药卫生—中药学]