新疆牧区哈萨克族原发性高血压患儿与血浆同型半胱氨酸的关系  

The relationship between homocysteine and essential hypertension in Kazakh adolescents from pasturing area of Xinjiang

作　　者：马兰红[1] 

机构地区：[1]新疆维吾尔自治区人民医院儿科,乌鲁木齐830000

出　　处：《国际儿科学杂志》2013年第4期410-413,共4页International Journal of Pediatrics

摘　　要：目的探讨新疆牧区哈萨克族原发性高血压患儿与血浆同型半胱氨酸的关系。方法选择来自新疆牧区的原发性高血压患儿84例（病例组），对照组100例，抽取空腹静脉血，检测血浆同型半胱氨酸水平，分析原发性高血压与血同型半胱氨酸的关系。结果在校正性别、年龄、体重指数、高血压家族史后，与对照组相比，病例组患儿的血同型半胱氨酸水平增高（P〈0．001）；Logistic分析结果提示随着血同型半胱氨酸水平的增高，高血压的患病风险增高（OR=10．23，P〈0．001）；偏相关分析结果提示血浆同型半胱氨酸水平与收缩压和舒张压均呈正相关（r=0．722，P〈0．001；与r=0．534，P〈0．001）。结论新疆牧区哈萨克族儿童高血压及血压水平与血浆同型半胱氨酸水平相关，血浆同型半胱氨酸水平增高是新疆牧区哈萨克族儿童高血压的独立危险因素。Objective To investigate the relationship between homocysteine and essential hypertension in Kazakh adolescent from pasturing area of Xinjiang. Methods We recruited 84 patients with essential hyper- tension（ case group） and 100 controls without hypertension（ control group）. Fasting blood were obtained from all subjects. Then we measured the homocysteine levels in all subjects. We analyzed the relationship between ho- mocysteine and essential hypertension in Kazakh adolescent from pasturing area of Xinjiang finally. Results After adjusting of sex, age, body mass index, and family history, compared with the control group, the homocys- teine levels in case group increased and had significant difference （P 〈 0. 001 ）. The results of Logistic regression analysis suggested that after adjusting of sex, age, body mass index, and family history, the OR value of essential hypertention increased with homocysteine（ OR = 10. 23 ,P 〈 0. 001 ）. Positive correlation existed between plasma homocysteine levels and systolic blood pressure （ r = 0. 722, P 〈 0. 001 ）, and diastolic blood pressure （ r = 0. 534, P 〈0. 001 ） after adjusted of sex,age,body mass index,and family history by using partial correlation analysis. Conclusion In Kazakh adolescent from pastoral areas of Xinjiang, homocysteine was associated with essential hypertension and blood pressure level. The higher homocysteine level was an independent risk factor for essential hypertension in Kazakh adolescent from pasturing area of Xinjiang.

关 键 词：哈萨克族 儿童 原发性高血压 同型半胱氨酸 

分 类 号：R725.4[医药卫生—儿科]