胃蛋白酶在成人分泌性中耳炎发病中的作用  

Pepsin secretory otitis media in the role of adult

作　　者：汪志伟[1] 窦晓辉[1] 曾亮[1] 林文佳[2] 

机构地区：[1]珠海市人民医院,暨南大学附属珠海医院耳鼻咽喉科,广东珠海519000 [2]珠海市人民医院,暨南大学附属珠海医院泌尿外科,广东珠海519000

出　　处：《世界最新医学信息文摘》2013年第7期14-15,共2页World Latest Medicine Information Electronic Version

基　　金：2012年珠海市科技局课题，项目编号2012D0401990015

摘　　要：目的探讨胃蛋白酶在成人分泌性中耳炎发病中的作用。方法选择2011年2月至2012年2月，我科住院有胃咽反流病史的15例成人分泌性中耳炎患者的中耳积液设为实验组，同期无胃咽反流病史的中耳炎15例，设为对照组。检测两组中耳渗液的胃蛋白酶水平，分析实验组患者年龄对中耳胃蛋白酶浓度的影响，以及胃蛋白酶浓度对患者病情的影响，对比两组的GERD症状差异。结果实验组中9例患者的中耳渗液中含有胃蛋白酶，平均浓度为（198．2±335．9）ng／mL，中耳积液PH值为6-2～7．4；对照组15例中耳渗液中没有检出胃蛋白酶。实验组胃蛋白酶的含量在各年龄上没有明显的差异。两组的GERD症状差异明显。结论胃蛋白酶可能是成人分泌性中耳炎发病因素之一，年龄对成人分泌性中耳炎患者中耳胃蛋白酶浓度无影响，胃蛋白酶浓度对患者病情有影响。Objective To investigate the pepsin secretory otitis media in the role of adult. Method Select 2011 February to 2012 February, 15 eases of hospitalized adult patients with secretory otitis media, for the observation group, the same period without otitis media and 15 cases of adult volunteers, as a control group. To observe the liquid penetration properties with pepsin in the ear. Statistical comparison, P 〈 0.05, there was statistical significance. Results The observation group of 9 cases of middle ear exudate containing pepsin, the average concentration of （198.2 ±335.9） ng/mL, middle ear effusion pH was 6.2- 7.4, comparison group; 15 volunteers was not detected in the middle ear of pepsin. There were no significant differences in the contents of pepsin in each age; the questionnaire results showed symptoms of GERD difference between the two groups was not obvious. Conclusion Pepsin is an important factor in adult secretory otitis media. Middle age on adults with secretory otitis media patients had no effect on concentration of pepsin, pepsin concentration have effects on patients.

关 键 词：胃蛋白酶 成人 分泌性中耳炎 胃食管反流 

分 类 号：R764.2[医药卫生—耳鼻咽喉科]