奥拉西坦对颅脑损伤大鼠的保护作用  

Protective effect of oxiracetam on traumatic brain injury in rats

作　　者：李建伟[1,2] 杨东军 陈旭义[1] 梁海乾[1] 

机构地区：[1]武警后勤学院附属医院脑系科中心,天津300162 [2]天津中医药大学,天津300193 [3]河北省霸州市第二医院脑外科,霸州065701

出　　处：《中国应用生理学杂志》2013年第4期298-300,共3页Chinese Journal of Applied Physiology

摘　　要：目的：研究奥拉西坦对颅脑损伤大鼠的保护作用。方法：Wistar大鼠30只,随机分为3组（n=10）：假手术组、模型组和治疗组。模型组和治疗组均采用Feeney法建立大鼠颅脑损伤（TBI）模型,假手术组只钻孔露骨,不予液压打击。治疗组术后给予奥拉西坦100 mg/（kg.d）灌胃,连续给药21 d。术后第1、4、7、14、21天对三组大鼠进行神经功能缺损评分。术后15~19 d进行Morris水迷宫测试,记录大鼠每日的平均逃避潜伏期、在目标象限内搜索时间及经过目标平台位置次数。结果：术后7,14,21 d,治疗组神经系统缺损评分明显低于模型组（P〈0.05）;术后16,17,18,19 d,模型组大鼠平均逃避潜伏期显著高于假手术组和治疗组（P〈0.05,P〈0.01）,模型组大鼠在目标象限内搜索时间及经过目标平台位置次数均显著低于假手术组和治疗组（P〈0.05）。结论：奥拉西坦能减轻颅脑损伤大鼠的神经损伤程度,增强对颅脑损伤大鼠的学习、记忆、空间认知能力。Objective： To study the role of oxiracetam on traumatic brain injury in rats.Methods： Thirty Wistar rats were randomly divided into 3 groups： sham operation group,model group and treatment group.Feeney method were used to establish traumatic brain injury（TBI） model in rats in model and treatment group,and rats in sham group were only broached without hydraumatic hitted.Rats in treatment group were successive administration for 21days with oxiracetam（100 mg/kg,ig）.Neurologic impairment scores were undertook after operation of 1 d,4 d,7 d,14 d and 21 d,and Morris water maze test were proceeded during 15 to 19 days after operation.Average escape latency,searching time in target quadrant and number of crossing target platform in rats were recorded.Results： Neurologic impairment scores of rats in treatment group were significantly less than those of model group after operation of 7,14 and 21 d（P＆lt;0.05）.Average escape latency of model group were significantly higher than those of sham operation group and treatment group（P＆lt;0.05,P＆lt;0.01）.Searching time in target quadrant and number of crossing target platform of model group were lower than those of sham operation and treatment group（P＆lt;0.05））.Conclusion： Oxiracetam could decrease neural injury and increase ability of learning,memory and space cognition in traumatic brain injury rats.

关 键 词：奥拉西坦 颅脑损伤 神经功能缺损 Morris水迷宫测试 

分 类 号：R651[医药卫生—外科学]