骨质疏松症椎体压缩骨折非手术综合治疗疗效观察  

Clinical observation of the efficacy of non-surgical comprehensive therapy on osteoporotic vertebral compression fractures

作　　者：叶进[1] 孔西建[1] 吴丹[1] 

机构地区：[1]河南省洛阳正骨医院,洛阳471002

出　　处：《中国骨质疏松杂志》2013年第7期728-731,共4页Chinese Journal of Osteoporosis

摘　　要：目的观察非手术综合治疗原发骨质疏松症合并椎体压缩性骨折的临床疗效。方法选择符合纳入条件的63例骨质疏松骨折住院病人,住院期间给予钙剂、活性维生素D、降钙素药物治疗,配合运动疗法、中药熏洗及脉冲电磁场骨质疏松治疗仪综合治疗,出院后给予钙剂、活性维生素D、阿仑膦酸钠巩固治疗6个月,通过治疗前后疼痛及功能活动量化评分,骨密度及骨代谢生化指标比较,进行疗效判定。结果综合疗法治疗骨质疏松症所致椎体压缩性骨折63例,治疗后3天、7天、15天疼痛评分与治疗前相比明显降低(P<0.01、P<0.001、P<0.001),差异有统计学意义;治疗后15天功能活动评分与治疗前相比明显降低(P<0.001),差异有统计学意义;治疗后6个月腰椎BMD、T值与治疗前相比明显升高(P<0.05,P<0.001),差异有统计学意义;治疗后3个月BAP与治疗前相比明显升高(P<0.05),β-CTX与治疗前相比明显降低(P<0.01),差异有统计学意义。结论综合疗法治疗原发性骨质疏松症合并椎体压缩性骨折,近期在缓解疼痛,改善功能活动,远期在抑制骨吸收、促进骨形成、提高骨密度方面具有较好的疗效。Objective To observe the clinical efficacy of non-surgical comprehensive treatment of primary osteoporosis combined with vertebral compression fractures. Methods Sixty-three patients with osteoporotic fractures who met the inclusion criteria were selected. During hospitalization, patients were treated with calcium, active vitamin D, and calcitonin drugs, combining with exercise therapy, comprehensive treatment of herbal fumigation, and pulsed electromagnetic field osteoporosis treatment. After discharging, calcium, active vitamin D, and alendronate were given to consolidate the treatment for 6 months. The efficacy was determined through the comparison of the pain and functional activity of quantitative score, bone mineral density, and bone metabolic and biochemical indicators. Results In comprehensive therapy for 63 patients with vertebral compression fractures caused by osteoporosis, pain score at day 3, day 7, and day 15 after the treatment was significantly lower than that before the treatment （P 〈 0. 01, P 〈 0. 001, and P 〈 0. 001, respectively）. After a 15-day treatment, the functional activity score was significant lower than that before the treatment （P 〈 0. 001 ）. After a 6-month treatment, BMD of the lumbar vertebrae and T value were significantly higher than those before the treatment （ P 〈 0.05, P 〈 0. 001 ）. After a 3-month treatment, BAP was significantly higher than that before the treatment （P 〈 0. 05 ）. β-CTX was significantly lower than that before the treatment （ P 〈 0. 01 ）. Conclusion Comprehensive therapy has a good effect on the treatment of primary osteoporosis combined with vertebral compression fractures, in terms of relieving pain and improving function in the short term, and on inhibition of bone absorption, promoting bone formation, and increasing bone mineral density in the long term.

关 键 词：骨质疏松 脊柱骨折 综合疗法 

分 类 号：R681[医药卫生—骨科学]