金属蛋白酶在骨关节炎表达的研究进展  

Research progress of the metalloproteinase expression in osteoarthritis

作　　者：阮佳莉[1] 田京[2] 

机构地区：[1]广州市南方医科大学珠江医院,广州510282 [2]广州市南方医科大学附属珠江医院骨科中心,510282

出　　处：《中国骨质疏松杂志》2013年第7期748-754,共7页Chinese Journal of Osteoporosis

摘　　要：目的探讨金属蛋白酶在骨关节炎中的作用和表达机制及其影响因素。方法由第一作者应用计算机检索PubMed、中国期刊全文数据库(CNKI)、维普数据库和万方数据库1997-05/2012-08相关文献。在标题、摘要、关键词中以"Osteoarthritis;Proteinase;Cartilage;Cartilage matrix;Metalloprotease"或"骨关节炎;蛋白酶;软骨;金属蛋白酶;软骨基质"为检索词进行检索。选择文章内容与金属蛋白酶有关者,同一领域文献则选择近期发表在权威杂志文章进行分析。结果初检得到206篇文献,排除134篇不符合标准的文献,共纳入72篇符合标准的文献。结论经分析得出金属蛋白酶在骨关节炎中起着重要的作用,其基因表达由多种因子参与转录调控,而其酶活性由相关抑制因子或活化因子抑制或活化其活性,此外,机械负荷也参与调控金属蛋白酶的活性。Objective Background Metalloproteinase, which causes the degradation of cartilage matrix, plays an important role in osteoarthritis. Objective To investigate the role of metalloproteinases in osteoarthritis, and to explore its expression mechanism and influencing factors. Methods A computer-based online search of PubMed database, CNKI database, VIP database, and Wanfang database was performed to search related articles. Osteoarthritis, Proteinase, Cartilage, Cartilage matrix, and Metalloprotease were used for word retrieval in the title, abstract, and keywords. Papers concerned with pulsed electromagnetic fields were selected. Literatures of the same fields recently published in authoritative journals were also included for analysis. Results At the beginning, 206 articles were included. Then 134 were excluded because of not conforming to standard literatures. Conclusion Metalloproteinases plays an important role in osteoarthritis, and a variety of factors are involved in transcriptional regulation of its gene expression. And its enzyme activity is inhibited or activated by inhibiting factors or activating factors. In addition, the mechanical load is also involved in the regulation of MMP activity.

关 键 词：骨关节炎 蛋白酶 软骨 金属蛋白酶 软骨基质 综述 

分 类 号：R68[医药卫生—骨科学]