酒精性股骨头缺血性坏死与CYP450关系研究进展  

Research progress in the relationship between alcohol-induced avascular necrosis of the femoral head and CYP450

作　　者：李盛华[1] 孙凤歧[2] 周明旺[1] 郭铁峰[2] 穆欢喜[2] 

机构地区：[1]甘肃省中医院,兰州730050 [2]甘肃中医学院,兰州730000

出　　处：《中国骨质疏松杂志》2013年第7期773-776,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(81072821/H2710)

摘　　要：目的长期过量饮酒引起的股骨头缺血性坏死(osteoarthrosis of femoral head,ONFH)是一种严重威胁人类健康的疾病,多发于20～50岁的青壮年。随着人们生活方式的改变,酒精性股骨头坏死的临床病例日渐增多,酒精性股骨头坏死(alcohol-induced osteoarthrosis of femoral head,AIONFH)的发病机制尚不完全清楚,很多学者认为主要与一些基因有关,各国学者报道情况不一,各持己见;本文就国内外酒精性股骨头坏死与CYP450的关系作一综述。Osteoarthrosis of the femoral head （ONFH）, which is caused by long term over-dose alcohol drinking and happens mostly in young adults at the age of 20 - 50 years old, is a disease that severely threatens human health. Along with the changes of people ＂s lifestyle, clinical cases of alcohol-induced ANFH （AIONFH） increase gradually. The pathogenesis of AIANFH remains unclear. Some scholars consider that this disease is related to some genes, but scholars from different countries have diverse reports and different opinions. This paper reviews the relationship between AIANFH and CYP450 from the national and internatinnal studies.

关 键 词：酒精性 股骨头坏死 CYP450 研究进展 

分 类 号：R681[医药卫生—骨科学]