三小汤加味对慢性阻塞模型大鼠血清内IL-8、TNF-ɑ的影响  

Effects of Three Small Soup on IL-8、TNF-ɑin Serum of COPD Model Rats

作　　者：曾荣南[1] 陈宝田[1] 

机构地区：[1]南方医科大学南方医院中医科,广州510515

出　　处：《数理医药学杂志》2013年第4期454-456,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨中药复方三小汤治疗慢性阻塞性肺病急性期的作用机制。方法:以气管注脂多糖加熏烟方法制备慢阻肺急性发作期模型。通过观察给药前后各组大鼠咳嗽频率变化,并用双抗体夹心ABC-ELISA法检测大鼠血清内IL-8、TNF-ɑ含量。观察大鼠模型给药前后的变化。结果:三小汤高剂量组、中剂量组与模型组比较显著降低模型大鼠咳嗽次数(P<0.05);三小汤高、中、低剂量组与模型组比较显著降低IL-8、TNF-ɑ含量。讨论:三小汤可以缓解慢性阻塞性肺病引起的咳嗽,降低血清内IL-8、TNF-ɑ含量可能是其疗效机制之一。Objective： To investigate the herbal compound three small soup treatment of chronic obstruc- tive pulmonary disease acute phase of the mechanism of action. Methods： Tracheal injection of lipopolysac- charide plus fume prepared COPD acute exacerbation of the model. By observing the rats before and after ad- ministration of cough frequency changes by double antibody sandwich ABC-ELISA assay serum IL-8、TNF-α content. Changes in the rat model before and after administration were observed. Results： Three small soup high-dose group, middle dose group and model group is significantly lower rat model of cough number of times （P〈0.05） ; three small soup high, medium, low dose group and model group comparison significant with the lowering of IL-8、TNF-α content. Donclusions： Three small soup can relieve cough caused by chronic obstructive pulmonary disease （COPD）, lower serum IL-8、TNF-α content may be one of the mecha- nisms of its efficacy.

关 键 词：三小汤 慢性阻塞性肺病 急性发作期 IL-8 TNF-ɑ 

分 类 号：R947[医药卫生—药剂学]