糖肾康丸急性毒性实验  

Experimental Study of Acute Toxicity ofTangshenkang Pill

作　　者：彭宣灏 孙江桥[2] 

机构地区：[1]湖北洪湖市中医医院,湖北洪湖433200 [2]湖北中医药大学,湖北武汉430065

出　　处：《辽宁中医药大学学报》2013年第8期36-37,共2页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探讨糖肾康丸对小鼠的急性毒性反应。方法:取40只小鼠分别按体重随机分为糖肾康丸组(20只)和蒸馏水组(20只),实验前禁食不禁水12 h,糖肾康丸按小鼠可灌服的最大体积(0.04 mL/g)灌服最大可灌服浓度的糖肾康丸浓稠液(5.28 g/mL),蒸馏水组小鼠灌服最大体积(0.04 mL/g)。一次性口服灌胃给药后,连续观察14 d,记录小鼠的毒性反应及死亡情况。结果:观察期间动物饮食和活动正常,毛色光泽,生长良好,未见任何中毒表现,无死亡。14 d后处死小鼠,肉眼观察各器官及脏器指数均无异常。结论:小鼠最大耐受量为211.2 g/kg,该量已为临床用量22.50 g的468倍以上,可以认为临床用药安全。Objective： To observe the acute toxic reaction of Tangshenkang Pill in mice. Methods： 40 mice were randomly divided into the treatment group （ n--20 ） and the control group （ n=20 ） for acute toxic reaction. All mice only took water without food for 12 h before experiment. The treatment group were irrigated Tangshenkang Pill （ extract concentration was 5.28 g/mL ） according to mice＇s maximal volume of stomach （ 0.04 mL/g ）, and the normal control group took NS with the same volume （ 0.04 mL/g ） one day at a time. The toxicity reaction and death situations were observed for 14 d. Results ： Diet, activities, color and luster of hair were normal, and there was no toxicity reaction and no mice died within 14 days . Conclusion ： The maximal tolerable dosage （ MTD ） of Tangshenkang Pill is above 211.2 g/kg in mice, which is more than 468 times of the clinical dosage. The drug is considered safe in clinical application.

关 键 词：糖肾康丸 急性毒性 最大耐受量 小鼠 

分 类 号：R285.5[医药卫生—中药学]